{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:31:43Z","timestamp":1791901903794,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003842","name":"Ilhan Food Allergy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      An altered compositional signature and reduced diversity of early gut microbiota are linked to development of allergic disease. We investigated the relationship between dominant\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      species during the early post\u2010natal period and subsequent development of allergic disease in the first year of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Faecal samples were collected at age 1 week, 1 month and 3 months from 117 infants at high risk of allergic disease.\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      species were analysed by quantitative\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      and terminal restriction fragment length polymorphism. Infants were examined at 3, 6 and 12 months, and skin prick test was performed at 12 months. Eczema was diagnosed according to the\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      Working Party criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The presence of\n                      <jats:italic>B. catenulatum<\/jats:italic>\n                      at 3 months was associated with a higher risk of developing eczema (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      <jats:sub>adj<\/jats:sub>\n                      = 4.5; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.56\u201313.05, p\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.005). Infants colonized with\n                      <jats:italic>B. breve<\/jats:italic>\n                      at 1 week (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.29; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.09\u20130.95, p\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.04) and 3 months (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.15; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.05\u20130.44, p\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.00001) had a reduced risk of developing eczema. Furthermore, the presence of\n                      <jats:italic>B. breve<\/jats:italic>\n                      at 3 months was associated with a lower risk of atopic sensitization at 12 months (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.38; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.15\u20130.98, p\n                      <jats:sub>adj<\/jats:sub>\n                      = 0.05).\n                      <jats:italic>B. breve<\/jats:italic>\n                      colonization patterns were influenced by maternal allergic status, household pets and number of siblings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Temporal variations in\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      colonization patterns early in life are associated with later development of eczema and\/or atopic sensitization in infants at high risk of allergic disease. Modulation of the early microbiota may provide a means to prevent eczema in high\u2010risk infants.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12646","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T02:56:59Z","timestamp":1472871419000},"page":"838-846","source":"Crossref","is-referenced-by-count":59,"title":["Early gut colonization by\n                    <i>Bifidobacterium breve<\/i>\n                    and\n                    <i>B. catenulatum<\/i>\n                    differentially modulates eczema risk in children at high risk of developing allergic disease"],"prefix":"10.1111","volume":"27","author":[{"given":"Intan H.","family":"Ismail","sequence":"first","affiliation":[{"name":"Murdoch Childrens Research Institute Melbourne Vic. Australia"},{"name":"The University of Melbourne Melbourne Vic. 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