{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:10:33Z","timestamp":1774995033763,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007919","name":"Chest Heart and Stroke Scotland","doi-asserted-by":"publisher","award":["R14\/A155"],"award-info":[{"award-number":["R14\/A155"]}],"id":[{"id":"10.13039\/501100007919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood asthma is a common condition whose prevalence is changing. We hypothesized that the relationship between asthma and associated risk factors has changed over a 50\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An ecological study design was used. Children aged 8\u201313 attending schools in Aberdeen city were surveyed on seven occasions between 1964 and 2014. The following were determined: history of asthma, history of eczema, parental smoking, parental asthma, sex and socio\u2010economic status. Analysis was by a structural change model with two knots. The outcome reported was the change in odds ratio between asthma and a given risk factor during a given period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 23,241 questionnaires distributed and 17,439 returned (75%). The odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) for a child with asthma to have eczema increased between 1989 and 1999 by 1.031 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.028, 1.035] and by 1.042 between 2004 and 2014 [1.038, 1.047]. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for a child with asthma to have a parent who smoked rose by 1.032 [1.028, 1.036] between 1989 and 1999 and by 1.043 [1.038, 1.047] between 2004 and 2014), and to have a parent with asthma (1.027 [1.022, 1.031] for 1994\u201399 and 1.042 [1.037, 1.048] for 2004\u20132014). The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for a child with asthma being male, but not and being from the most deprived communities, rose between 1989\u20131999 and 2004\u20132014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relationship between asthma prevalence and particular risk factors changed over the 50\u2010year period of study, and this might reflect changes in children's environment and\/or susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12674","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T15:16:59Z","timestamp":1477408619000},"page":"162-169","source":"Crossref","is-referenced-by-count":9,"title":["Changes in the relationship between asthma and associated risk factors over fifty years"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-6548","authenticated-orcid":false,"given":"Maxwell S.","family":"Barnish","sequence":"first","affiliation":[{"name":"Child Health University of Aberdeen Aberdeen UK"},{"name":"Epidemiology Group University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nara","family":"Tagiyeva","sequence":"additional","affiliation":[{"name":"Child Health University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Devereux","sequence":"additional","affiliation":[{"name":"Child Health University of Aberdeen Aberdeen UK"},{"name":"Institute of Medical Sciences University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Aucott","sequence":"additional","affiliation":[{"name":"Medical Statistics University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Turner","sequence":"additional","affiliation":[{"name":"Child Health University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organisation.Chronic Respiratory Diseases. 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