{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:34:36Z","timestamp":1761863676485,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81261130023","81370129"],"award-info":[{"award-number":["81261130023","81370129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have assessed the time trends of prevalence of symptoms of rhinitis (SR) with wheezing and their associations in Chinese adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the trend of prevalence of SR with wheezing and allergen sensitization in adolescents during the past 15\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 6928 adolescents aged 13\u201314\u00a0years in 2009 were recruited for the study using the Phase III Protocol of the International Study of Asthma and Allergic disease in Childhood (ISAAC) and allergic sensitization to seven inhalant allergens in 2531 was assessed by skin prick test in 2010. The results were compared to those obtained in the Phase I (1994\/95) and III (2001\/02) ISAAC studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of \u2018SR ever\u2019 and \u2018current symptoms of rhino\u2010conjunctivitis\u2019 increased from 46.3% and 8.7% in 1994 to 53.2% and 11.1% in 2001 (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), respectively, and remained stable at 52.6% and 10.4% in 2009 (p<jats:italic>\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). The prevalence of \u2018SR ever and wheeze ever\u2019 and \u2018SR ever and current wheeze\u2019 increased from 6.2% and 3.4% in 1994 to 8.6% and 4.8% in 2001 (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) to 10.9% and 5.9% in 2009 (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). The sensitization rate to common inhaled allergens was higher in 2010 than in 2002 (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Sensitization to house dust mites (HDMs) was associated with increases in the prevalence of SR (OR, 2.06\u20132.86), especially with coexistence of wheeze (OR, 6.07\u20137.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of symptoms of rhinitis and coexistence with wheezing has increased significantly since 1994. Sensitization to HDMs is the main risk factor associated with this increase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12709","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T21:36:37Z","timestamp":1487972197000},"page":"340-347","source":"Crossref","is-referenced-by-count":9,"title":["Allergen sensitization affected the change trend of prevalence of symptoms of rhinitis coexisting with wheeze among adolescents in Guangzhou City from 1994 to 2009"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-8928","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"The school of Medicine The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"The Department of Medicine Firestone Institute for Respiratory Health The Research Institute of St. Joe's Hamilton, St.Joseph's Healthcare McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W. K.","family":"Wong","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou 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