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Large epidemiologic studies have demonstrated a clear relationship between\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    infection and subsequent recurrent wheezing and asthma into childhood, thought to be predominantly related to long\u2010term changes in neuroimmune control of airway tone rather than to allergic sensitization. These changes appear to be governed by the severity of the first\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    infection in infancy which in term depends on viral characteristics and load, but perhaps as importantly, on the genetic susceptibility and on the constitutional characteristic of the host. A variety of viral and host factors and their interplay modify the efficiency of the response to infection, including viral replication and the magnitude of structural and functional damage to the respiratory structures, and ultimately the extent, severity, and duration of subsequent wheezing.\n                  <\/jats:p>","DOI":"10.1111\/pai.12716","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T04:01:41Z","timestamp":1490414501000},"page":"320-331","source":"Crossref","is-referenced-by-count":43,"title":["Respiratory syncytial virus\u2013Host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-9042","authenticated-orcid":false,"given":"Giovanni A.","family":"Rossi","sequence":"first","affiliation":[{"name":"Pulmonary and Allergy Disease Pediatric Unit and Cystic Fibrosis Center Istituto Giannina Gaslini 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