{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:37:40Z","timestamp":1789652260095,"version":"4.0.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of infant feeding practices on the development of food allergy remains controversial. We examined the relationship between timing and patterns of food introduction and sensitization to foods at age 1\u00a0year in the Canadian Healthy Infant Longitudinal Development (<jats:styled-content style=\"fixed-case\">CHILD<\/jats:styled-content>) birth cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nutrition questionnaire data prospectively collected at age 3, 6, 12, 18, and 24\u00a0months were used to determine timing of introduction of cow's milk products, egg, and peanut. At age 1\u00a0year, infants underwent skin prick testing to cow's milk, egg white, and peanut. Logistic regression models were fitted to assess the impact of timing of food exposures on sensitization outcomes, and latent class analysis was used to study patterns of food introduction within the cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2124 children with sufficient data, delaying introduction of cow's milk products, egg, and peanut beyond the first year of life significantly increased the odds of sensitization to that food (cow's milk adj<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.37\u20109.08; egg adj<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.89, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.25\u20102.80; peanut adj<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.76, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.07\u20103.01). Latent class analysis produced a three\u2010class model: early, usual, and delayed introduction. A pattern of delayed introduction, characterized by avoidance of egg and peanut during the first year of life, increased the odds of sensitization to any of the three tested foods (adj<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.78, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.26\u20102.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Avoidance of potentially allergenic foods during the first year of life significantly increased the odds of sensitization to the corresponding foods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12739","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T13:36:42Z","timestamp":1496065002000},"page":"471-477","source":"Crossref","is-referenced-by-count":56,"title":["Timing of food introduction and development of food sensitization in a prospective birth cohort"],"prefix":"10.1111","volume":"28","author":[{"given":"Maxwell M.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Dharma","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja","family":"Subbarao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Lou","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan B.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Child Health University of Manitoba  Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Child Health University of Manitoba  Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piush J.","family":"Mandhane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart E.","family":"Turvey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-4917","authenticated-orcid":false,"given":"Malcolm R.","family":"Sears","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CHILD Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.346"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61364-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1803"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2521"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1651"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0813"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.039"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.028"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2012.09.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12398"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.045"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207246"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11025-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.023"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514210"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12623"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.052"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12608"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7038.1074"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1746"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013536"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12231"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12226"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:28:14Z","timestamp":1695486494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/pai.12739"],"URL":"https:\/\/doi.org\/10.1111\/pai.12739","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}