{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:23:22Z","timestamp":1791347002239,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Danish National University Hospital \u201cRigshospitalet.\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis has been increasing. Register\u2010based studies are essential for research in subpopulations with specific diseases and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease\u2010specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated. This study validated the algorithms vs gold standard deep telephone interviews with the caretaker about physician\u2010diagnosed atopic dermatitis, wheezing, asthma or allergic rhinoconjunctivitis in the child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The algorithms defined each of the three atopic diseases using register\u2010based information on disease\u2010specific hospital contacts and\/or filled prescriptions of disease\u2010specific medication. Confirmative answers to questions about physician\u2010diagnosed atopic disease were used as the gold standard for the comparison with the algorithms, resulting in sensitivities and specificities and 95% confidence intervals. The interviews with the caretaker of the included 454 Danish children born 1997\u20102003 were carried out May\u2010September 2015; the mean age of the children at the time of the interview being 15.2\u00a0years (standard deviation 1.3\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the algorithm capturing children with atopic dermatitis, the sensitivity was 74.1% (95% confidence interval: 66.9%\u201080.2%) and the specificity 73.0% (67.3%\u201078.0%). For the algorithm capturing children with asthma, both the sensitivity of 84.1% (78.0%\u201088.8%) and the specificity of 81.6% (76.5%\u201085.8%) were high compared with physician\u2010diagnosed asthmatic bronchitis (recurrent wheezing). The sensitivity remained high when capturing physician\u2010diagnosed asthma: 83.3% (74.3%\u201089.6%); however, the specificity declined to 66.0% (60.9%\u201070.8%). For allergic rhinoconjunctivitis, the sensitivity was 84.4% (78.0\u201089.2) and the specificity 81.6% (75.0\u201084.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The algorithms are valid and valuable tools to identify children with atopic dermatitis, wheezing, asthma or allergic rhinoconjunctivitis on a population level using register data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12743","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T12:46:45Z","timestamp":1497962805000},"page":"535-542","source":"Crossref","is-referenced-by-count":42,"title":["The validity of register data to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-153X","authenticated-orcid":false,"given":"Lone Graff","family":"Stensballe","sequence":"first","affiliation":[{"name":"The Child and Adolescent Clinic 4072 Juliane Marie Centret Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Klans\u00f8","sequence":"additional","affiliation":[{"name":"The Child and Adolescent Clinic 4072 Juliane Marie Centret Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jensen","sequence":"additional","affiliation":[{"name":"The Child and Adolescent Clinic 4072 Juliane Marie Centret Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"H\u00e6rskjold","sequence":"additional","affiliation":[{"name":"The Child and Adolescent Clinic 4072 Juliane Marie Centret Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Dermato\u2010Allergology Herlev and Gentofte Hospital University of Copenhagen  Hellerup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital &amp; Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00554.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0226"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01073.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_6_9_1","first-page":"263","article-title":"The Danish national hospital register. 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