{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:03:18Z","timestamp":1773280998598,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>House dust mite (HDM<\/jats:styled-content>) respiratory allergy is a common and burdensome disease in children and adolescents. There are few HDM<\/jats:styled-content> allergy immunotherapy trials in children with perennial allergic rhinitis. This post hoc analysis used pooled data to evaluate efficacy and safety of the SQ HDM<\/jats:styled-content> sublingual immunotherapy (SLIT<\/jats:styled-content>) tablet in adolescents (12\u201017\u00a0years).<\/jats:p><\/jats:sec>Methods<\/jats:title>In two double\u2010blind, placebo\u2010controlled trials conducted in North America and Japan, respectively, subjects aged 12+ years with HDM<\/jats:styled-content> allergic rhinitis were randomized to up to 1\u00a0year of treatment. The primary end\u2010point in both trials was the average total combined rhinitis score (TCRS<\/jats:styled-content>) during the last 8\u00a0weeks of treatment in the active group compared with placebo. Data from subjects aged 12\u201017\u00a0years were pooled (N=395).<\/jats:p><\/jats:sec>Results<\/jats:title>In the pooled adolescent subpopulation, average TCRS<\/jats:styled-content> improved 22% with 12 SQ HDM<\/jats:styled-content> vs placebo (absolute treatment difference of 1.04; P<\/jats:italic><.01). Rhinitis daily symptom score (DSS<\/jats:styled-content>), conjunctivitis DSS<\/jats:styled-content> and rhinitis daily medication score (DMS<\/jats:styled-content>) were also significantly improved vs placebo in the pooled adolescent subpopulation (all P<\/jats:italic><.05). There were no new safety signals for adolescents. The frequency of adverse events was similar in adolescents and adults with the majority being mild application site\u2010related events.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Treatment with 12 SQ HDM<\/jats:styled-content> appears to be effective and well tolerated in adolescents with HDM<\/jats:styled-content> allergic rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12747","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T07:12:38Z","timestamp":1498720358000},"page":"661-667","source":"Crossref","is-referenced-by-count":23,"title":["Pooled efficacy and safety data for house dust mite sublingual immunotherapy tablets in adolescents"],"prefix":"10.1111","volume":"28","author":[{"given":"Tomokazu","family":"Matsuoka","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery Faculty of Medicine Graduate Faculty of Interdisciplinary Research University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Bernstein Clinical Research Center and Division of Allergy and Immunology University of Cincinnati Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery Faculty of Medicine Graduate Faculty of Interdisciplinary Research University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Nolte","sequence":"additional","affiliation":[{"name":"Research and Development ALK H\u00f8rsholm Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Okamiya","sequence":"additional","affiliation":[{"name":"Clinical Development Department Torii Pharmaceutical Co. 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