{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:27:37Z","timestamp":1768868857649,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF108"],"award-info":[{"award-number":["DNRF108"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008244","name":"Direkt\u00f8r Jacob Madsen og Hustru Olga Madsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaccination with Bacillus Calmette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) is used in many countries as protection against tuberculosis. Studies have suggested that <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> may also have non\u2010specific effects, reducing non\u2010tuberculosis mortality, morbidity, and atopic manifestations. In this study, we evaluated the effect of neonatal <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccination on allergic sensitization and suspected food allergy at 13\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals. Within 7\u00a0days of birth, the 4262 newborns of 4184 included mothers were randomized 1:1 to <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> or to a no\u2010intervention control group. Exclusion criteria were gestational age &lt;32\u00a0weeks, birth weight &lt;1000\u00a0g, known immunodeficiency, or no Danish\u2010speaking parent. Follow\u2010up information was collected through telephone interviews at 3 and 13\u00a0months of age. Subgroups of participants were offered blood sampling at 13\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By 13\u00a0months of age, the parents and\/or general practitioners of 5.6% (117\/2089) of the children in the <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> group and 6.1% (126\/2061) of the control group suspected food allergy, resulting in a risk ratio comparing <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\u2010vaccinated children with control children of 0.91 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.71\u20101.16). Among 1370 blood samples, sensitization (Phadiatop Infant &gt;0.35\u00a0kUA\/L) was found in 55 of 743 (7.4%) children in the <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> group and 50 of 627 (8.0%) of the control group (risk ratio 0.94 [0.65\u20101.36]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this randomized clinical trial, neonatal <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> had no significant effect on suspected food allergy or on sensitization at 13\u00a0months of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12748","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T07:32:45Z","timestamp":1498721565000},"page":"588-596","source":"Crossref","is-referenced-by-count":25,"title":["Neonatal <scp>BCG<\/scp> has no effect on allergic sensitization and suspected food allergy until 13\u00a0months"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-1260","authenticated-orcid":false,"given":"Lisbeth Marianne","family":"Th\u00f8stesen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kolding Hospital  Kolding Denmark"},{"name":"Institute of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Fomsgaard","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Allergy Centre and Department of Dermatology Odense University Hospital  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte Thybo","family":"Pihl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kolding Hospital  Kolding Denmark"},{"name":"Institute of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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