{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:31:51Z","timestamp":1790015511544,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Food allergy is a significant medical problem that affects up to 8% of children in developed countries. At present, there are no curative therapies available in routine practice and management of food allergy involves strict allergen avoidance, education, and prompt treatment upon accidental exposure. Oral immunotherapy (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>) is an efficacious experimental approach to food allergy and has been shown to provide a substantial benefit in terms of allergen desensitization. However, <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> is associated with high rates of allergic reactions, and the period of protection offered by <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> appears to be limited and highly variable. Recurrence of allergen sensitivity after a period of treatment discontinuation is commonly observed. With the aim of overcoming these limitations of <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>, several trials have studied omalizumab (anti\u2010IgE monoclonal antibody) as an adjuvant treatment for patients undergoing <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>. Results from these trials have shown that the addition of omalizumab to <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> leads to a significant decrease in the frequency and severity of reactions, which allows for an increase in the threshold of tolerance to food allergens. This review provides a summary of the current literature and addresses some of the key questions that remain regarding the use of omalizumab in conjunction with <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pai.12767","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:12:37Z","timestamp":1502093557000},"page":"619-627","source":"Crossref","is-referenced-by-count":47,"title":["Combining anti\u2010IgE with oral immunotherapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Chunrong","family":"Lin","sequence":"first","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanitha","family":"Sampath","sequence":"additional","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Dinakar","sequence":"additional","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie H.","family":"DeKruyff","sequence":"additional","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda C.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-2955","authenticated-orcid":false,"given":"Kari Christine","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Sean N. Parker Center for Allergy and Asthma Research at Stanford University  Stanford CA USA"},{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Stanford University  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000196"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-016-2358-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62258-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533613505870"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12748"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.034"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.12.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.1.3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.111"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13124"},{"key":"e_1_2_8_18_1","first-page":"CD009542","article-title":"Oral immunotherapy for milk allergy","volume":"11","author":"Yeung JP","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513002353"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03948.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01341.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03699.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0070-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-016-0420-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022613"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.051"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.039"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.044"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.060"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13044"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.050"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3819"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.046"},{"key":"e_1_2_8_38_1","unstructured":"Novartis.Omalizumab: Summary of product characteristics.http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/000606\/WC500057298.pdf. Accessed March 27 2017."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90135-2"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12259"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-7"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.045"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.022"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5499"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0143"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.007"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.006"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12400"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12584"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.005"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.053"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12567"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:53:56Z","timestamp":1695567236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/pai.12767"],"URL":"https:\/\/doi.org\/10.1111\/pai.12767","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]}}}