{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:01:46Z","timestamp":1781373706255,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Suspected allergy to penicillins and cephalosporins is very common in childhood. After a proper evaluation, allergy will be confirmed only in a small portion of them. Intradermal tests are usually part of the allergy workup, but they are painful for children and time\u2010consuming, and their role has been debated. A systematic review found only two studies reporting a positive predictive value of skin tests in children of 36% and 33%, respectively, leading to a high rate of inaccurate diagnosis. Moreover, considering that skin tests are negative in more than 90%\u201095% of cases, an oral provocation test (<jats:styled-content style=\"fixed-case\">OPT<\/jats:styled-content>) is finally needed to confirm tolerance in most of these children. Positive <jats:styled-content style=\"fixed-case\">OPT<\/jats:styled-content> are rare, and even where children demonstrate reproducible signs on challenge, they rarely constitute immediate or serious symptoms. Therefore, <jats:styled-content style=\"fixed-case\">OPT<\/jats:styled-content> to the index antibiotic without skin tests are increasingly being considered an accepted procedure for children with a suspected mild non\u2010immediate reaction related to a beta\u2010lactam antibiotic. Furthermore, a recent research has taken the same approach including children with suspected mild immediate reactions, with similar safety and positive results. In light of recent evidence highlighted, it is now the time for large and multicentric studies to confirm that <jats:styled-content style=\"fixed-case\">OPT<\/jats:styled-content> with the index antibiotic, without skin tests, are safe and convenient for children with a history of a mild reaction with a beta\u2010lactam antibiotic before it can be recommended in pediatric allergy guidelines.<\/jats:p>","DOI":"10.1111\/pai.12800","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:44:48Z","timestamp":1505144688000},"page":"724-727","source":"Crossref","is-referenced-by-count":44,"title":["Oral challenge without skin tests in children with non\u2010severe beta\u2010lactam hypersensitivity: Time to change the paradigm?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-6073","authenticated-orcid":false,"given":"Luis","family":"Moral","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Respiratory Unit Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christoph","family":"Caubet","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Department of Child and Adolescent University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12774"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12468"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1191319"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12314"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2010.10.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2010.01.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2014.04.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12493"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12565"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12557"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02228.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.045"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.03.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12155"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12269"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12423"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm315"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01169.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.04.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.05.033"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0033"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306280"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.042"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:31:12Z","timestamp":1695558672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/pai.12800"],"URL":"https:\/\/doi.org\/10.1111\/pai.12800","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}