{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:46:58Z","timestamp":1767847618104,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The K\u00fchne Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rehabilitational programs at moderate altitude (1500\u20102500\u00a0m) showed improvement of lung function and reduction in airways inflammation in asthmatic adults. Allergen avoidance was postulated as the major cause of these improvements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Spirometries of 344 and fractional exhaled nitric oxide measurements (Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) of 124 asthmatic children and adolescents, staying in a rehabilitation hospital in Davos (1590\u00a0m) with at least 14\u00a0days between admission and discharge, were analyzed in association with atopic sensitization (skin\u2010prick testing and\/or specific IgE), level of asthma control, and inhalative corticosteroid (<jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>) dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pulmonary conditions improved significantly on average during the sojourn. Uncontrolled asthmatics benefited most with an absolute increase in predicted FEV<jats:sub>1<\/jats:sub>, MEF<jats:sub>25<\/jats:sub>, and MEF<jats:sub>75<\/jats:sub> of 7.7%, 9.9%, and 12.7%, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> decreased by 36.9\u00a0ppb for uncontrolled, by 26.9\u00a0ppb for partly controlled, and by 11.8\u00a0ppb for controlled asthmatics. In uncontrolled subjects, pulmonary improvement was comparable between patients with and without house dust mites (<jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>) sensitization. Pulmonary improvements of pollen\u2010sensitized patients were not dependent on the season of the sojourn. For the group with constant <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> level, the absolute increase in FEV<jats:sub>1<\/jats:sub> was 4.9% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) with a Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> decreased by 32.7\u00a0ppb (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). When the <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> dose was elevated by one <jats:styled-content style=\"fixed-case\">GINA<\/jats:styled-content> level, the absolute increase in FEV<jats:sub>1<\/jats:sub> was slightly higher (6.6%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), with a Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> decrease of 31.4\u00a0ppb (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inpatient rehabilitation at moderate altitude improved pulmonary conditions in asthmatic children and adolescents independent of sensitization status to <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content> or pollen. A positive effect was also observed in patients without change in medication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12808","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T19:52:37Z","timestamp":1507233157000},"page":"768-775","source":"Crossref","is-referenced-by-count":24,"title":["Lung function improvement and airways inflammation reduction in asthmatic children after a rehabilitation program at moderate altitude"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-1786","authenticated-orcid":false,"given":"Eugen","family":"Bersuch","sequence":"first","affiliation":[{"name":"CK\u2010CARE Christine K\u00fchne Center for Allergy Research and Education  Davos Switzerland"},{"name":"Department of Dermatology Allergy Unit Zurich University Hospital  Zurich 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