{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:21:37Z","timestamp":1780384897107,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> at 6 and 14\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Danish Allergy Research Center (<jats:styled-content style=\"fixed-case\">DARC<\/jats:styled-content>) cohort is a prospective non\u2010interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow\u2010ups between 3 and 18\u00a0months of age (n\u00a0=\u00a0366). Multiple logistic regression models were used to investigate the association between transient and persistent early\u2010life sensitization to groups of and to individual allergens and asthma and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> at 6 and 14\u00a0years compared to a reference group with no sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both transient early\u2010life sensitization and persistent early\u2010life sensitization to cow's milk or hen's egg proteins were associated with asthma (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 3.99[1.41\u201011.32] and 5.95[1.78\u201019.92]) and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 2.94[1.19\u20107.28] and 6.18[1.86\u201020.53]) at 14\u00a0years, this association being driven mainly by sensitization to hen's egg. Transient early\u2010life sensitization to house dust mite (<jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>) had increased risk of asthma (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 3.80[1.17\u201012.41]) at 14\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> at 14\u00a0years. Furthermore, sensitization to <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content> was associated with asthma at 14\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12815","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T19:46:44Z","timestamp":1507232804000},"page":"776-783","source":"Crossref","is-referenced-by-count":15,"title":["Early\u2010life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14\u00a0years of age"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-2686","authenticated-orcid":false,"given":"Elisabeth Soegaard","family":"Christiansen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark  Odense Denmark"},{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Fomsgaard","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Eller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"H\u00f8st","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Gotthard","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense Research Centre for Anaphylaxis (ORCA) Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-8278","authenticated-orcid":false,"given":"Susanne","family":"Halken","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00305.x"},{"key":"e_1_2_6_3_1","first-page":"445","article-title":"The association between early sensitisation patterns and subsequent development of allergic disease. 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