{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:34Z","timestamp":1740124354134,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL080073"],"award-info":[{"award-number":["HL080073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cysteinyl\u2010leukotrienes are increased in the airways of infants with virus\u2010associated wheezing. We aimed to determine the effects of a cysteinyl\u2010leukotriene\u20101 receptor antagonist on symptoms during an early\u2010life wheezing illness and to investigate the factors that affect the response to this drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This placebo\u2010controlled double\u2010blinded randomized controlled trial recruited children aged 3\u201036\u00a0months with wheezing illness and randomized to active drug or placebo for 56\u00a0days. A symptom score diary (<jats:styled-content style=\"fixed-case\">SSD<\/jats:styled-content>) was kept by the children's caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred patients completed the study, and 62 (30 montelukast and 32 placebo) were analyzed. There were no significant differences in the percent of symptom\u2010free days, symptom scores, and the need for rescue salbutamol between the two groups. However, the percent of symptom\u2010free days within the first week was significantly higher for the montelukast than for the placebo group (13.8\u00a0\u00b1\u00a04.1% vs. 5.4\u00a0\u00b1\u00a03.4%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028); wheezing score at 7th day was significantly lower for the montelukast than for the placebo group (0.5\u00a0\u00b1\u00a00.1 vs. 1.4\u00a0\u00b1\u00a00.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). In addition, the number of inhaled \u00df<jats:sub>2<\/jats:sub>\u2010agonist rescue episodes per day during the first week was significantly lower for the montelukast compared with the placebo group (12.7\u00a0\u00b1\u00a01.8 vs. 19.2\u00a0\u00b1\u00a01.6; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that montelukast may be effective for reducing caregiver\u2010observed wheezing and the need for salbutamol during the first week of treatment for early\u2010life wheezing. The impact for caregivers and the optimal duration of treatment will need to be explored in studies of larger size.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1111\/pai.12822","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T08:00:28Z","timestamp":1508400028000},"page":"50-57","source":"Crossref","is-referenced-by-count":10,"title":["The effect of montelukast on early\u2010life wheezing: A randomized, double\u2010blinded placebo\u2010controlled study"],"prefix":"10.1111","volume":"29","author":[{"given":"Ozlem","family":"Keskin","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Gaziantep University School of Medicine  Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-2754","authenticated-orcid":false,"given":"Ebru","family":"Arik Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Motzkus","sequence":"additional","affiliation":[{"name":"Clinical and Population Health Research Program University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-9805","authenticated-orcid":false,"given":"Cansin","family":"Sackesen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"},{"name":"Department of Pediatric Allergy Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M.","family":"Lilly","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Anesthesiology, and Surgery University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Kalayci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.162"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00199913"},{"volume-title":"Bronchiolitis in children: diagnosis and management (NG9)","year":"2015","author":"National Institute for Health and Care Excellence (NICE)","key":"e_1_2_6_6_1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/317655"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.04.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2867"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000122604.32137.29"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-233OC"},{"key":"e_1_2_6_13_1","unstructured":"GINA.Report Global Strategy for Asthma Management and Prevention. 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