{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:24:11Z","timestamp":1744395851505,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (<jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content>) for allergy based on findings in adults and study its predictive capacity for allergy in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> was constructed based on 10 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s previously associated with allergies in adults. The <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> was tested in children who participated in a population\u2010based newborn cohort (<jats:styled-content style=\"fixed-case\">WHISTLER<\/jats:styled-content>) and were followed from birth to school age. Logistic regression analysis was used to study the association between the <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> and the parental\u2010reported allergies at age 5 (based on a reported allergy to \u22651 of the following allergens: pollen, house dust mites, or pets). A Cox regression model was used to study the association between <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> and a physician\u2010diagnosed allergy during follow\u2010up (allergic conjunctivitis, allergic rhinitis, and eczema\/dermatitis). Cohen's kappa coefficient was calculated to study the agreement between physician\u2010diagnosed allergy and parental\u2010reported allergy at age 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> was significantly associated with parental\u2010reported allergy (odds ratio: 15.9, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.07\u2010233.73) at age 5, as well as with a physician\u2010diagnosed allergy during follow\u2010up (hazard ratio: 1.89, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.05\u20103.41). The overall agreement between physician\u2010diagnosed and parental\u2010reported allergies was 70.5% (kappa: 0.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.03\u20100.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An adult\u2010derived <jats:styled-content style=\"fixed-case\">GRS<\/jats:styled-content> for allergy predicts the risk of developing allergies in childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12824","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T08:02:48Z","timestamp":1508400168000},"page":"72-77","source":"Crossref","is-referenced-by-count":7,"title":["The association between a genetic risk score for allergy and the risk of developing allergies in childhood\u2014Results of the <scp>WHISTLER<\/scp> cohort"],"prefix":"10.1111","volume":"29","author":[{"given":"Ali","family":"Arabkhazaeli","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Ahmadizar","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Leusink","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertus G. M.","family":"Arets","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology WKZ University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A. M.","family":"Raaijmakers","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuno S. P. M.","family":"Uiterwaal","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology WKZ University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-3442","authenticated-orcid":false,"given":"Anke\u2010Hilse","family":"Maitland\u2010van der Zee","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"},{"name":"Department of Respiratory Medicine Academic Medical Center (AMC) University of Amsterdam (UvA)  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-4081","authenticated-orcid":false,"given":"Susanne J. H.","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology &amp; Clinical Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"},{"name":"Department of Respiratory Medicine Academic Medical Center (AMC) University of Amsterdam (UvA)  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12327"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050242"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700739"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01358.x"},{"issue":"4","key":"e_1_2_5_7_1","first-page":"23","article-title":"Genetic markers of atopy in infancy: results from the German Multicenter Allergy Study","volume":"29","author":"Nickel R","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/75977"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02000.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00191.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2006.00635.x"},{"key":"e_1_2_5_12_1","first-page":"55","article-title":"Genetic variant rs4982958 at 14q11.2 is associated with allergic rhinitis in a Chinese Han population running title: 14q11.2 is a susceptibility locus for allergic rhinitis","volume":"22","author":"Tang XF","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-29"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02425.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12647"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.04.035"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-13-66"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2686"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099210"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt093"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000040530.98310.0c"},{"key":"e_1_2_5_22_1","unstructured":"Anonymous Exome Chip Design \u2013 Genome Analysis Wiki;2014."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts479"},{"key":"e_1_2_5_25_1","first-page":"809","article-title":"The International Classification of Primary Care (ICPC\u20102): an essential tool in the EPR of the GP","volume":"124","author":"Verbeke M","year":"2006","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00149-X"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4049\/jimmunol.1.3.201","article-title":"Human sensitization","volume":"1","author":"Cooke RA","year":"1916","journal-title":"J Immunol"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2694"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.08.002"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:13:09Z","timestamp":1695514389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/pai.12824"],"URL":"https:\/\/doi.org\/10.1111\/pai.12824","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"type":"print","value":"0905-6157"},{"type":"electronic","value":"1399-3038"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}