{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:37:43Z","timestamp":1776710263318,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cow's milk allergy (CMA<\/jats:styled-content>) affects 2% of all children. This study investigatescomponent\u2010resolved diagnostics(CRD<\/jats:styled-content>) to cow's milk proteins in children suspected of CMA<\/jats:styled-content>, by correlating the level of CRD<\/jats:styled-content> with outcome of the oral challenge. Furthermore, we evaluate the ability of serial CRD<\/jats:styled-content> measurements to distinguish children with persistent CMA<\/jats:styled-content> from children developing tolerance.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included data from 78 children referred to the Allergy Centre during a 13\u2010year period. Results from oral food challenges including threshold, severity, and sensitization data (IgE antibodies to whole milk protein, IgE components toward milk and skin prick test (SPT<\/jats:styled-content>)) were collected. The milk allergic children were re\u2010evaluated with sensitization data and rechallenges regularly.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010nine children had negative first challenges, and 39 had positive first challenges. The positive group was rechallenged and separated into 3 groups depending on time to remission. At inclusion, children with persistent CMA<\/jats:styled-content> had significantly larger size of SPT<\/jats:styled-content> and higher levels of s\u2010IgE to milk and CRD<\/jats:styled-content> compared to the other groups. SPT<\/jats:styled-content> wheal size was significantly larger in children with persistent CMA<\/jats:styled-content> compared to children outgrowing CMA<\/jats:styled-content>. Furthermore, a correlation between s\u2010IgE level to cow's milk and casein and the severity of the allergic reaction elicited by food challenges was found.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Oral food challenge cannot be replaced by s\u2010IgE to whole milk protein or milk components nor SPT<\/jats:styled-content> in the diagnosis of CMA<\/jats:styled-content>; however, high levels of milk components and s\u2010IgE to milk increase the risk of a long\u2010lasting or persisting CMA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12854","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T07:49:20Z","timestamp":1515052160000},"page":"194-199","source":"Crossref","is-referenced-by-count":35,"title":["Cow's milk allergic children\u2014Can component\u2010resolved diagnostics predict duration and severity?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-6031","authenticated-orcid":false,"given":"Thomas Houmann","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Dermatology & Allergy Center Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Gotthard","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Allergy Center Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Allergy Center Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"Eller","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Allergy Center Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1990.tb00944.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70393-3"},{"issue":"482","key":"e_1_2_6_4_1","first-page":"e1","article-title":"Natural course and risk factors for persistence of IgE\u2010mediated cow's milk allergy","volume":"161","author":"Elizur A","year":"2012","journal-title":"J Pediatr"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00371.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12820"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12644"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321108"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12075"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.10.063"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01976.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12001"},{"issue":"10","key":"e_1_2_6_18_1","first-page":"1","article-title":"Skin tests used in type I allergy testing Position paper. 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