{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:30:24Z","timestamp":1791862224492,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cohort studies have suggested that early\u2010life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk of atopic and non\u2010atopic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The INCA study is a prospective observational birth cohort study of 436 term infants, with follow\u2010up of 1\u00a0year; 151 neonates received broad\u2010spectrum antibiotics for suspected neonatal infection (AB+), vs a healthy untreated control group (N\u00a0=\u00a0285; AB\u2212). In the first year, parents recorded daily (non\u2010) allergic symptoms. At 1\u00a0year, doctors\u2019 diagnoses were registered and a blood sample was taken (n\u00a0=\u00a0205).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence of wheezing in the first year was higher in AB+ than AB\u2212 (41.0% vs 30.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026; aOR 1.56 [95%CI 0.99\u20102.46, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06]). Infantile colics were more prevalent in AB+ compared to AB\u2212 (21.9% and 14.4% <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048), and antibiotic treatment was an independent risk factor for infantile colics (aOR 1.66 (95%CI 1.00\u20102.77) <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05). Allergic sensitization (Phadiatop &gt;0.70kUA\/L) showed a trend toward a higher risk in AB+ (aOR 3.26 (95%CI 0.95\u201011.13) <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). Incidence of eczema, infections, and GP visits in the first year were similar in AB+ and AB\u2212.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibiotic treatment in the first week of life is associated with an increased risk of wheezing and infantile colics. This study may provide a rationale for early cessation of antibiotics in neonates without proven or probable infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12857","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T09:47:01Z","timestamp":1515059221000},"page":"151-158","source":"Crossref","is-referenced-by-count":49,"title":["Wheezing and infantile colic are associated with neonatal antibiotic treatment"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-5296","authenticated-orcid":false,"given":"Berthe C.","family":"Oosterloo","sequence":"first","affiliation":[{"name":"Academic Medical Center Emma Children's Hospital  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruurd M.","family":"van Elburg","sequence":"additional","affiliation":[{"name":"Academic Medical Center Emma Children's Hospital  Amsterdam the Netherlands"},{"name":"Nutricia Research  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Rutten","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin M.","family":"Bunkers","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa E.","family":"Crijns","sequence":"additional","affiliation":[{"name":"Ter Gooi Hospital  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens B.","family":"Meijssen","sequence":"additional","affiliation":[{"name":"Meander Medical Center  Amersfoort the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna H.","family":"Oudshoorn","sequence":"additional","affiliation":[{"name":"Gelre Hospital  Apeldoorn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger T.","family":"Rijkers","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"University College Roosevelt  Middelburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Wilhelmina Children's Hospital University Medical Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arine M.","family":"Vlieger","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00109"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2847"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.30-38.2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111142"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.32"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0519-0"},{"key":"e_1_2_7_9_1","unstructured":"Guideline; 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