{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:42:11Z","timestamp":1788471731503,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010761","name":"Svenska F\u00f6reningen f\u00f6r Allergologi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P29398\u2010B30"],"award-info":[{"award-number":["P29398\u2010B30"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Rhinovirus\u2010induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin\u2010related family member 3 (\n CDHR<\/jats:styled-content>\n 3) was identified as the\n RV<\/jats:styled-content>\n \u2010C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced\n RV<\/jats:styled-content>\n \u2010C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and\n mRNA<\/jats:styled-content>\n expression of\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age\u2010matched healthy children.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n rs6967330;G>A was genotyped (n\u00a0=\u00a0216), and\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n mRNA<\/jats:styled-content>\n expression was measured in peripheral blood leukocytes (n\u00a0=\u00a069) from a subgroup of children wheezing with\n RV<\/jats:styled-content>\n infection acute and at a follow\u2010up visit 2\u20103\u00a0months later, and in healthy controls. Standardized TaqMan assays were used.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The risk allele rs6967330\u2010A was over\u2010represented in the wheezing group (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .001). Reduced\n mRNA<\/jats:styled-content>\n levels of\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n were found in children with acute wheezing as compared to the control group (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n .001). Children with the rs6967330 genotypes\n AA<\/jats:styled-content>\n \/\n AG<\/jats:styled-content>\n showed the largest differences in\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n expression between acute and follow\u2010up visit (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Preschool children with\n RV<\/jats:styled-content>\n \u2010induced wheezing were shown to have reduced\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n mRNA<\/jats:styled-content>\n levels, which might result in an increased permeability of the epithelial layers of the airways and thereby an increased vulnerability. Thus, measuring\n \n CDHR<\/jats:styled-content>\n 3\n <\/jats:italic>\n mRNA<\/jats:styled-content>\n levels might help to identify a more severe phenotype of wheezing preschool children.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.12858","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T04:45:05Z","timestamp":1515041105000},"page":"200-206","source":"Crossref","is-referenced-by-count":25,"title":["Reduced\n \n CDHR<\/scp>\n 3\n <\/i>\n expression in children wheezing with rhinovirus"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-8280","authenticated-orcid":false,"given":"Katarina","family":"Stenberg Hammar","sequence":"first","affiliation":[{"name":"Department of Women\u2032s and Children\u2032s Health Karolinska Institutet Stockholm Sweden"},{"name":"Astrid Lindgren Children\u2032s Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Centre of Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Niespodziana","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"van Hage","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit Department of Medicine, Solna Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Kere","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden"},{"name":"Molecular Neurology Research Program University of Helsinki and Folkh\u00e4lsan Institute of Genetics Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Hedlin","sequence":"additional","affiliation":[{"name":"Department of Women\u2032s and Children\u2032s Health Karolinska Institutet Stockholm Sweden"},{"name":"Astrid Lindgren Children\u2032s Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Centre of Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8397-3080","authenticated-orcid":false,"given":"Cilla","family":"S\u00f6derh\u00e4ll","sequence":"additional","affiliation":[{"name":"Department of Women\u2032s and Children\u2032s Health Karolinska Institutet Stockholm Sweden"},{"name":"Centre of Allergy Research Karolinska Institutet Stockholm Sweden"},{"name":"Department of Biosciences and Nutrition Karolinska Institutet Stockholm 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