{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:46:24Z","timestamp":1788993984989,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stallergenes Greer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The overlapping grass and olive pollen seasons in Spain and the phenomenon of cross\u2010reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the <jats:styled-content style=\"fixed-case\">GRAMOLE<\/jats:styled-content> study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians\u2019 choice of allergen\u2010specific immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Epidemiological, observational, multicenter, cross\u2010sectional study. Results from children under 18\u00a0years of age diagnosed with seasonal allergic rhinitis by positive skin prick tests to olive and grass pollen were analyzed. Specific IgE to Phl p 1+5, Ole e 1, and Phl p 7+12 was determined. Investigators specified the optimal composition of allergen immunotherapy before and after knowing the results of the molecular diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 281 patients with a mean age of 13.4\u00a0years were included. Double sensitization to both major allergens was found in vitro in 76% of children for an IgE cutoff point of 0.35\u00a0kU\/L. When the molecular diagnosis results were known, specialists changed the composition of the prescribed immunotherapy in 52.87% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Double sensitization to grass and olive pollen is common in Spain and also occurs in the pediatric population. Molecular diagnosis using specific IgE may help improve immunotherapy selection in polysensitized patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12866","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T15:56:53Z","timestamp":1516895813000},"page":"369-374","source":"Crossref","is-referenced-by-count":26,"title":["Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen"],"prefix":"10.1111","volume":"29","author":[{"given":"Ana","family":"Mart\u00ednez\u2010Ca\u00f1avate Burgos","sequence":"first","affiliation":[{"name":"Department of Pediatrics Head of Pediatric Allergy Unit H. 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