{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:05Z","timestamp":1787015885290,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["HRC 11\/318"],"award-info":[{"award-number":["HRC 11\/318"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In a randomized placebo\u2010controlled trial, we previously found that the probiotic\n                      <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 (\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001) taken by mothers from 35\u00a0weeks of gestation until 6\u00a0months post\u2010partum if breastfeeding and their child from birth to age 2\u00a0years halved the risk of eczema during the first 2\u00a0years of life. We aimed to test whether maternal supplementation alone is sufficient to reduce eczema and compare this to our previous study when both the mother and their child were supplemented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this 2\u2010centre, parallel double\u2010blind, randomized placebo\u2010controlled trial, the same probiotic as in our previous study (\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001, 6\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      colony\u2010forming units) was taken daily by mothers from 14\u201016\u00a0weeks of gestation till 6\u00a0months post\u2010partum if breastfeeding, but was not given directly to the child. Women were recruited from the same study population as the first study, where they or their partner had a history of treated asthma, eczema or hay fever.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women were randomized to\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 (N\u00a0=\u00a0212) or placebo (N\u00a0=\u00a0211). Maternal\u2010only\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 supplementation did not significantly reduce the prevalence of eczema,\n                      <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>\n                      \u00a0\u2265\u00a010, wheeze or atopic sensitization in the infant by 12\u00a0months. This contrasts with the mother and child intervention study, where\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 was associated with reductions in eczema (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ): 0.39, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.19\u20100.79,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009) and\n                      <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a00.61, 95% 0.37\u20101.02). However, differences in the\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 effect between studies were not significant.\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 could not be detected in breastmilk from supplemented mothers, and breastmilk\n                      <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                      \u2010\u03b2\/IgA profiles were unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal probiotic supplementation without infant supplementation may not be effective for preventing infant eczema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12874","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T15:38:40Z","timestamp":1518017920000},"page":"296-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Maternal supplementation alone with\n                    <i>Lactobacillus rhamnosus<\/i>\n                    <scp>HN<\/scp>\n                    001 during pregnancy and breastfeeding does not reduce infant eczema"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-6005","authenticated-orcid":false,"given":"Kristin","family":"Wickens","sequence":"first","affiliation":[{"name":"University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Barthow","sequence":"additional","affiliation":[{"name":"University of Otago  Wellington New 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