{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:26:02Z","timestamp":1790717162994,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lallemand Pharma AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Despite progress in asthma management, prevention of asthma exacerbation remains challenging in school\u2010aged children with allergic asthma. New therapeutic approaches are needed. Previously, a chemical bacterial lysate has been successfully used in preschool children to reduce wheezing attacks. We assessed the effect of Polyvalent Mechanical Bacterial Lysate (\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n ) Tablet on asthma clinical course and control in 6\u2010 to 16\u2010year\u2010old children with partly controlled or uncontrolled allergic asthma.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group study was performed in 152 patients exhibiting allergic asthma assigned to receive Placebo or\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n . Eligible patients underwent four visits during the 9\u2010month study. Asthma control level was assessed by\n ACT<\/jats:styled-content>\n \/C\u2010\n ACT<\/jats:styled-content>\n score.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The main criterion was not achieved as\n ACT<\/jats:styled-content>\n \/C\u2010\n ACT<\/jats:styled-content>\n changes were similar in both groups at the end of the 3\u2010month treatment period. However, the mean number (\u00b1\n SD<\/jats:styled-content>\n ) of asthma exacerbations was significantly lower with\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n Tablet than with Placebo at Week 12 (0.3\u00a0\u00b1\u00a00.6 vs 0.8\u00a0\u00b1\u00a01.1,\n P\u00a0=\u00a0<\/jats:italic>\n .009) and over the total study period (1.1\u00a0\u00b1\u00a01.3 vs 1.9\u00a0\u00b1\u00a02.0,\n P\u00a0=\u00a0<\/jats:italic>\n .01). Consistently, the mean number of days with exacerbation per patient was significantly lower with\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n Tablet (13.3\u00a0\u00b1\u00a011.2 vs 19.8\u00a0\u00b1\u00a015.7 over the whole study,\n P\u00a0=\u00a0<\/jats:italic>\n .009). Treatment with\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n Tablet prolonged the time to second exacerbation by 55% (Hazard Ratio [\n HR<\/jats:styled-content>\n ]=0.45; 95% Confidence Interval [\n CI<\/jats:styled-content>\n ] 0.27 to 0.77,\n P\u00a0=\u00a0<\/jats:italic>\n .002) and to third exacerbation by 74% (\n HR<\/jats:styled-content>\n =0.26; 95%\n CI<\/jats:styled-content>\n 0.12 to 0.58,\n P\u00a0<\u00a0<\/jats:italic>\n .001). No serious adverse event related to\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n Tablet administration was recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Administration of\n PMBL<\/jats:styled-content>\n \u00ae<\/jats:sup>\n Tablet represents a safe and effective means for significantly reducing the rate of exacerbations in school\u2010aged allergic asthmatic children. (Eudra\n CT<\/jats:styled-content>\n 2013\u2010000737\u201012 and\n NCT<\/jats:styled-content>\n 02541331)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.12894","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T12:11:20Z","timestamp":1521979880000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mechanical bacterial lysate administration prevents exacerbation in allergic asthmatic children\u2014The\n EOLIA<\/scp>\n study"],"prefix":"10.1111","volume":"29","author":[{"given":"Andrzej","family":"Emeryk","sequence":"first","affiliation":[{"name":"Department of Paediatric Pulmonology and Rheumatology University Children Hospital of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Bartkowiak\u2010Emeryk","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Raus","sequence":"additional","affiliation":[{"name":"LaserMed Diagnosis and Treatment Centre Che\u0142m Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Braido","sequence":"additional","affiliation":[{"name":"Allergy and Respiratory Diseases Department University of Genoa, IRCCS A.O.U San Martino\u2010 IST Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferlazzo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Biotherapy Department of Human Pathology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Melioli","sequence":"additional","affiliation":[{"name":"Allergy and Respiratory Diseases Department University of Genoa, IRCCS A.O.U San Martino\u2010 IST Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0172-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-24"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.039"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045179"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61380-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.09.60"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0344-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.042523"},{"key":"e_1_2_7_13_1","unstructured":"Global Initiative for Asthma \u2010 GINA.http:\/\/ginasthma.org\/. 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