{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:34:00Z","timestamp":1793723640569,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K00899"],"award-info":[{"award-number":["16K00899"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16ek0410019\u00a0h0002"],"award-info":[{"award-number":["16ek0410019\u00a0h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Oral food challenges (OFC<\/jats:styled-content>s) are necessary to diagnose food allergies; however, these tests can cause anaphylaxis. Higher specific immunoglobulin E (sIgE<\/jats:styled-content>) levels to causative food have been associated with a positive OFC<\/jats:styled-content>. To date, no data have been found to indicate the factors associated with severe symptoms or anaphylaxis among challenge\u2010positive patients. This study aimed to clarify the association of sIgE<\/jats:styled-content> with causative foods and anaphylaxis during OFC<\/jats:styled-content> among the whole study population and challenge\u2010positive patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>This cross\u2010sectional study collected symptom and severity data between June 2012 and December 2016 during an open OFC<\/jats:styled-content> to diagnose food allergy or confirm tolerance acquisition. We analyzed the risk factors for anaphylaxis during OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 2272 cases were analyzed (median age: 3.5\u00a0years; egg: 1166 cases; milk: 589 cases; wheat: 388 cases; and peanut: 129 cases). Among 979 challenge\u2010positive patients, anaphylactic reactions were observed in 334 cases. A statistically significant association was observed between anaphylaxis during OFC<\/jats:styled-content> and higher sIgE<\/jats:styled-content> levels to causative foods (odds ratio: 2.71, 95% confidence interval: 1.94\u20103.78, for the third compared to the first tertile, P<\/jats:italic>\u2010value for trend <.001). Only gastrointestinal, respiratory, cardiovascular, and neurological symptoms were also statistically significantly associated with higher sIgE<\/jats:styled-content> levels to causative foods.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The risk of all symptoms, except skin symptoms, during OFC<\/jats:styled-content>s increased with increasing sIgE<\/jats:styled-content> levels, and this consequently increased anaphylaxis during OFC<\/jats:styled-content>s. The mechanism of how sIgE<\/jats:styled-content> affects the prevalence of gastrointestinal, respiratory, cardiovascular, and neurological symptoms or anaphylaxis is unknown; thus, further study is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12896","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:37:18Z","timestamp":1522003038000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Increasing specific immunoglobulin E levels correlate with the risk of anaphylaxis during an oral food challenge"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-744X","authenticated-orcid":false,"given":"Noriyuki","family":"Yanagida","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-5421","authenticated-orcid":false,"given":"Tomoyuki","family":"Asaumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotake","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital Sagamihara\u2010City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-558X","authenticated-orcid":false,"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology Sagamihara National Hospital Sagamihara\u2010City Kanagawa 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