{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:18Z","timestamp":1791389898837,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["201414009A"],"award-info":[{"award-number":["201414009A"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ek0410019\u00a0h0003"],"award-info":[{"award-number":["17ek0410019\u00a0h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral immunotherapy (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>) is a promising treatment for persons with allergy; however, it can also cause adverse allergic reactions. In this study, we investigated the efficacy of low\u2010dose <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> for anaphylactic peanut allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four children (median age, 9.6\u00a0years) with anaphylaxis to peanuts were hospitalized for 5\u00a0days and then gradually fed increasing amounts of peanut powder up to 133\u00a0mg\/day. One year later, they underwent an oral food challenge after 2\u00a0weeks of peanut avoidance. Those who were asymptomatic after ingesting 795\u00a0mg of peanut protein were defined as having achieved sustained unresponsiveness. We measured peanut\u2010 and Ara h2\u2010specific immunoglobulin (Ig) E, IgG, and IgG4 levels at 0, 1, 3, 6, and 12\u00a0months in the <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> group and at 0 and 12\u00a0months in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, all children in the <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> group and 8 in the control group had a history of anaphylaxis. The median peanut\u2010\/Ara h2\u2010specific IgE levels in the <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> and control groups were 55.4\/48.6 and 58.2\/38.1\u00a0kUa\/L, respectively. One year later, 8 (33.3%) children in the <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> group exhibited sustained unresponsiveness, while none in the control group did. In the <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> group, the median peanut\u2010specific IgE levels significantly increased to 194.0\u00a0kUa\/L, after 1\u00a0month and then significantly decreased to 57.5\u00a0kUa\/L at 12\u00a0months. Meanwhile, the median peanut\u2010 and Ara h2\u2010specific IgG and IgG4 levels increased significantly after 1\u00a0month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> induces immunological changes and has the capability of achieving sustained unresponsiveness in children with peanut anaphylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12898","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T05:22:50Z","timestamp":1522473770000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Low\u2010dose oral immunotherapy for children with anaphylactic peanut allergy in Japan"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-9044","authenticated-orcid":false,"given":"Ken\u2010ichi","family":"Nagakura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital  Kanagawa Japan"},{"name":"Department of Pediatrics Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sagamihara National Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Allergy Clinical Research Center for Allergy and Rheumatology Sagamihara National Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of 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