{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:46:07Z","timestamp":1776815167525,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergen\u2010specific IgE levels can be useful in predicting outcomes of oral food challenges, but optimal cutoff levels vary in different populations. The aim was to determine cutoff values for egg white\u2010 and Gal d 1\u2010, Gal d 2\u2010, Gal d 3\u2010, and Gal d 4\u2010specific IgE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) predicting positive oral heated egg challenges in 185 Finnish children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 185 egg\u2010sensitized patients (age: 1\u201019\u00a0years, median: 6.3, mean: 7.0\u00a0years) with suspected egg allergy underwent double\u2010blind, placebo\u2010controlled (n\u00a0=\u00a078), or open (n\u00a0=\u00a0107) oral food challenges with heated egg white. Specific IgE levels to egg white, Gal d 1 (ovomucoid), Gal d 2 (ovalbumin), Gal d 3 (conalbumin), and Gal d 4 (lysozyme) were measured by Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and compared with challenge outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 185 challenges, 124 (67%) were positive. Gal d 1 <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> levels were significantly higher in the challenge\u2010positive (median 13.5\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L, mean 33.2\u00a0kU\/L) than in the challenge\u2010negative group (median 0.2\u00a0kU\/L, mean 1.2\u00a0kU\/L), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001. The diagnostic capacity of <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> to egg white and Gal d 2, 3, and 4 was clearly weaker. In <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis, the <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> for egg white was 0.86, Gal d 2 0.84, Gal d 3 0.79, and Gal d 4 0.77. Sensitization to Gal d 1 with a cutoff of value of &gt;3.7\u00a0kU\/L predicted a positive challenge with a specificity of 95% and sensitivity of 78%. The likelihood ratio was 15.9. In <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis, the area under the curve was 0.94 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.91\u20100.97). With a cutoff value of &gt;14\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L, all challenges were positive, and with a cutoff of &lt;0.9\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L, 95% of the challenges were negative. In the children aged 1\u20105\u00a0years (n\u00a0=\u00a088), the cutoff for Gal d 1 was &gt;3.8\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L, and in the children above 6\u00a0years of age (n\u00a0=\u00a097), it was &gt;3.5\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gal d 1\u2010specific IgE is useful in distinguishing egg\u2010sensitized patients with clinically reactive egg allergy from those tolerant of heated egg. The optimal cutoff point in a Finnish population of 185 children and adolescents was 3.7\u00a0kU\/L with no significant difference between the younger and older age groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12954","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T06:54:25Z","timestamp":1530687265000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Gal d 1\u2010specific IgE predicts allergy to heated egg in Finnish children"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-0439","authenticated-orcid":false,"given":"Kati","family":"Palosuo","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna 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