{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:32:53Z","timestamp":1792013573119,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Thermo-Fisher South Africa"},{"name":"Allergy Society of South Africa"},{"DOI":"10.13039\/100002806","name":"Discovery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002806","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Paediatrics"},{"name":"Nestl\u00e9 Nutrition Institute Africa"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe meat allergy with anaphylaxis may be caused by sensitization to alpha\u2010gal. Levels of alpha\u2010gal sensitization that correlate with high risk of meat allergy are currently unknown. We have identified an area with a high prevalence of reported red meat allergy which offered the opportunity to evaluate the diagnostic value of IgE antibody tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To determine levels of alpha\u2010gal IgE and alpha\u2010gal:total IgE ratio in a large cohort of subjects with challenge\u2010proven meat allergy compared with control subjects from the same environment, we conducted fieldwork assessing 131 participants who reported adverse reactions to meat, and 26 control subjects, by questionnaires, IgE sensitization to alpha\u2010gal and oral food challenge to beef sausage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010four participants were diagnosed with alpha\u2010gal allergy. Alpha\u2010gal IgE ranged between 0.7 and 344.5\u00a0kU\/L. Alpha\u2010gal:total IgE ratio ranged from 0.1% to 67.6%. Logistic regression analysis showed both alpha\u2010gal IgE and alpha\u2010gal:total IgE ratio strongly correlated with meat allergy, with\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      of 0.95. The values giving the best correct classification were IgE of 2.00\u00a0\n                      <jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\n                      \/L and ratio of 0.75%. The value above which there is a 95% probability of meat allergy is IgE&gt;5.5\u00a0kU\/L and ratio of 2.12%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alpha\u2010gal allergy in a population with a high prevalence of reported red meat allergy showed a more rapid onset of symptoms than previously described and a high prevalence of isolated subjective gastrointestinal manifestations. Cutoff values are described for levels of sensitization to alpha\u2010gal IgE and alpha\u2010gal:total IgE ratio that are highly likely to result in clinically significant meat allergy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.12969","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T09:41:32Z","timestamp":1535103692000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Predictive values of alpha\u2010gal IgE levels and alpha\u2010gal IgE: Total IgE ratio and oral food challenge\u2010proven meat allergy in a population with a high prevalence of reported red meat allergy"],"prefix":"10.1111","volume":"29","author":[{"given":"Tshegofatso","family":"Mabelane","sequence":"first","affiliation":[{"name":"Department of Paediatric Allergology University of Cape Town  Cape Town South 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