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A complete evaluation of the patients based on reported clinical manifestations, timing of the reaction, the presence of underlying disease, and reactions to other <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s allows clinicians to stratify children with a history of reaction to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s. Although <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010induced hypersensitivity reactions have mainly been investigated in adults, recent studies have aimed to explore their epidemiology in the pediatric population. This review will cover the current understanding of clinical manifestations, the risk factors, and the different phenotypes of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010induced hypersensitivity reactions with a comprehensive overview of the epidemiologic data from past to present and the practical approach to the management of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity in children and adolescents.<\/jats:p>","DOI":"10.1111\/pai.12980","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T14:04:16Z","timestamp":1536415456000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Characteristics of <scp>NSAID<\/scp>\u2010induced hypersensitivity reactions in 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