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We analyzed immune and growth factor concentrations in early BM and their association with maternal\/environmental characteristics and with food allergy (FA) in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n\u00a0=\u00a02002 mother\u2010child dyads). A random selection was performed among available samples (subcohort, n\u00a0=\u00a0272), for which all deliveries were full\u2010term, various maternal\/environmental characteristics were recorded, and parents answered yearly the question \u201cHas a medical doctor diagnosed a FA in your child?\u201d (26 parent\u2010reported FA cases). Only samples collected between day 2 and day 6 post\u2010partum were considered for descriptive analysis (n\u00a0=\u00a0263). Samples for all other FA cases available were added to the subcohort (46 additional cases; \u201ccasecohort\u201d design). Fifty cytokines, antibodies, and growth factor concentrations were determined using multiplexed kits and analyzed using robust statistical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BM components exhibited wide concentration ranges and global day\u2010to\u2010day variation. Different clusters of correlated factors appeared, with components from the main cluster related to maternal diet during pregnancy. Primiparity was positively associated with eleven other components, whereas other factors (eg, maternal atopy and smoking) were related to fewer components. Finally, the casecohort design highlighted a positive association between CXCL10, TNF\u03b2, and IL\u20102 concentrations and reported FA in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Beyond the unique description of early BM composition, we show that immune information transmitted to the neonate is related to various maternal factors and identified components associated with FA diagnosis in childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12998","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T06:33:32Z","timestamp":1540708412000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood"],"prefix":"10.1111","volume":"30","author":[{"given":"Mika\u00efl","family":"Berdi","sequence":"first","affiliation":[{"name":"UMR Service de Pharmacologie et Immunoanalyse, Laboratoire d\u2019Immuno\u2010Allergie Alimentaire, CEA, INRA Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"},{"name":"UMR Service de Pharmacologie et Immunoanalyse, Laboratoire d\u2019Etude du M\u00e9tabolisme des M\u00e9dicaments CEA, INRA Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"de Lauzon\u2010Guillain","sequence":"additional","affiliation":[{"name":"INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Center Early Origin of the Child\u2019s Health and Development Team (ORCHAD) Paris France"},{"name":"Paris Descartes University Paris 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Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"},{"name":"UMR Service de Pharmacologie et Immunoanalyse, Laboratoire d\u2019Etude du M\u00e9tabolisme des M\u00e9dicaments CEA, INRA Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-0626","authenticated-orcid":false,"given":"Karine","family":"Adel\u2010Patient","sequence":"additional","affiliation":[{"name":"UMR Service de Pharmacologie et Immunoanalyse, Laboratoire d\u2019Immuno\u2010Allergie Alimentaire, CEA, INRA Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EDEN Mother\u2010Child Cohort Study 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