{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:13:54Z","timestamp":1793279634305,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colombian Government","award":["325-2006"],"award-info":[{"award-number":["325-2006"]}]},{"name":"Colombian Government","award":["515-2012"],"award-info":[{"award-number":["515-2012"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In tropical zones, perennial exposure to house dust mite (HDM) allergens and helminth infections is present. Studying the impact of these conditions on the inception and evolution of allergic diseases is necessary to have an accurate view of their natural history. We aimed to evaluate the dynamics of genuine sensitization to <jats:italic>Blomia tropicalis<\/jats:italic> and Ascaris in children from the FRAAT birth cohort and the effects of helminth infection, environmental HDM allergen levels, and sociodemographic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children were followed up to 6\u00a0years old. Specific IgE to recombinant allergens from <jats:italic>B.\u00a0tropicalis<\/jats:italic> (Blo t 5 and Blo t 12) and Ascaris spp (Asc l 3, Asc l 13 and Asc s 1) was measured by ELISA at different time points. Allergen levels were measured in dust when children were 6\u00a0months old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgE sensitization increased over time up to 3\u00a0years old. Correlation among the specific IgE levels to <jats:italic>B.\u00a0tropicalis<\/jats:italic> and Ascaris components is poor at year 1, but coefficients are high and significant (Spearman's rho coefficients &gt;0.70) at year 6. Unhygienic conditions increased the odds of sensitization to <jats:italic>B.\u00a0tropicalis<\/jats:italic> allergenic components. Blo t 5 levels were lower in the poorest. IgE response to Blo t 5 and Blo t 12 was less intense in children with high exposure to Blo t 5 (levels &gt;80th percentile).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this tropical community, the pattern of childhood IgE sensitization is different from that in developing countries and is influenced by the hygienic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13004","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T10:58:12Z","timestamp":1542106692000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hygienic conditions influence sensitization to <i>Blomia tropicalis<\/i> allergenic components: Results from the FRAAT birth cohort"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-5376","authenticated-orcid":false,"given":"Josefina","family":"Zakzuk","sequence":"first","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilia","family":"Mercado","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Bornacelly","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"},{"name":"Group of Clinical and Experimental Allergy University of Antioquia  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velky","family":"Ahumada","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-1109","authenticated-orcid":false,"given":"Luis","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"},{"name":"Foundation for the Development of Medical and Biological Sciences (Fundemeb) Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","first-page":"281","article-title":"Sensitization to mite allergens and acute asthma in a tropical environment","volume":"8","author":"Caraballo L","year":"1998","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0110-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb00325.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-13"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12161"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02084.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03193.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-11"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321106"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078353"},{"key":"e_1_2_7_12_1","article-title":"Will today's poor be tomorrow's poor? 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