{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:36:42Z","timestamp":1790152602478,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:00:00Z","timestamp":1548547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-07-PNRA-0023"],"award-info":[{"award-number":["ANR-07-PNRA-0023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hen's egg food allergy is frequent in childhood and phenotypically heterogeneous. Some children can tolerate extensively heated egg. We investigated whether individual relative responses could differentiate children who tolerate baked egg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reactivities to raw, pasteurized or hard\u2010boiled egg (E), egg white (EW), and egg yolk (EY) fractions were tested by skin prick test (SPT) in 54 egg\u2010allergic children. IgE\u2010sensitization to EW and EY was determined by ImmunoCAP and IgE\u2010binding to EW and 8 EW proteins and to EY and 4 EY sub\u2010fractions by ELISA. Population heterogeneity was assessed by hierarchical ascending classification upon individual variations of reactivity and links between classifications and clinical features by analyzing the contingency tables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All children had positive SPT to raw E and raw EW and 72% to raw EY. Heating decreased SPT\u2010reactivity for some children, pasteurization being less effective than hard\u2010boiling. Children were classed into three classes from relative SPT\u2010reactivity to raw fractions, two from variations of SPT\u2010reactivity with each thermal processing or EW\/EY ratio of sensitization, and four from their sensitization pattern. Classifications according to heating were found independent of each other. SPT variations with hard\u2010boiling, IgE\u2010sensitization (ratio or pattern) were linked to allowance by the physicians of egg in baked products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Egg\u2010allergic children were often both sensitized to EY and EW, and heterogeneous patterns of relative responses were evidenced. Irrespective of age and level of sensitization, a low EW\/EY ratio or SPT getting null with hard\u2010boiling was found in children allowed to eat baked egg.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13009","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T14:20:46Z","timestamp":1543242046000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relative reactivity to egg white and yolk or change upon heating as markers for baked egg tolerance"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-1583","authenticated-orcid":false,"given":"Chantal","family":"Brossard","sequence":"first","affiliation":[{"name":"INRA UR 1268 Biopolym\u00e8res, Interactions, Assemblages Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Ranc\u00e9","sequence":"additional","affiliation":[{"name":"CHU Toulouse \u2010 P\u00e9diatrie \u2010 Pneumologie, Allergologie Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Drouet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Allergologie G\u00e9n\u00e9rale, D\u00e9partement Pneumologie CHU d'Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Paty","sequence":"additional","affiliation":[{"name":"CHU Necker Pneumo Allergologie Infantile Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Juchet","sequence":"additional","affiliation":[{"name":"CHU Toulouse \u2010 P\u00e9diatrie \u2010 Pneumologie, Allergologie Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gu\u00e9rin\u2010Dubiard","sequence":"additional","affiliation":[{"name":"Agrocampus Ouest UMR1253 Sciences et Technologie du Lait et de l'\u0152uf Rennes France"},{"name":"INRA 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