{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:28:04Z","timestamp":1790785684670,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Natural course and co\u2010occurrence of asthma, eczema, and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity, and apparent triggers of respiratory\/allergy symptoms in school\u2010aged children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on occurrence, severity, and triggers of asthma, rhinitis, and dermatitis symptoms were collected annually during the follow\u2010up of the PARIS birth cohort. Children with similar symptom trajectories until 8\u20109\u00a0years were grouped into profiles using multidimensional (all symptoms considered simultaneously) cluster analysis. Associations between profiles and different health outcomes were analyzed using logistic or linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six distinct symptomatic profiles were identified. A profile was defined by persistent dermatitis symptoms, associated with sensitization to food and aeroallergens. Two profiles were characterized by wheezing: one with early transient wheezing and the other with persistent wheezing related to doctor\u2010diagnosed asthma, airway obstruction, and perennial aeroallergen sensitization. Three profiles were characterized by rhinitis symptoms: one non\u2010allergic and two allergic, either with persistent rhinitis symptoms related to allergic multimorbidity and sensitization to perennial aeroallergens, or with late\u2010onset symptoms, related to both pollen and perennial aeroallergens sensitization as well as low lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study brings further insights into the developmental profiles of respiratory\/allergic outcomes from birth to school age. The identified profiles clearly differed regarding objective features such as diagnosed morbidity, sensitization, or lung function measurements, thus highlighting their biologic and clinical relevance. Allergic rhinitis profiles deserve particular attention, since they were likely to be involved in multimorbidity patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13027","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T13:09:00Z","timestamp":1548421740000},"page":"315-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Unsupervised trajectories of respiratory\/allergic symptoms throughout childhood in the PARIS cohort"],"prefix":"10.1111","volume":"30","author":[{"given":"Nicolas","family":"Bougas","sequence":"first","affiliation":[{"name":"INSERM UMR 1153 \u2010 CRESS, HERA (Health Environmental Risk Assessment) research unit Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-2429","authenticated-orcid":false,"given":"Jocelyne","family":"Just","sequence":"additional","affiliation":[{"name":"Service d\u2019Allergologie P\u00e9diatrique, AP\u2010HP H\u00f4pital d\u2019Enfants Armand\u2010Trousseau Paris France"},{"name":"Universit\u00e9 Paris Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Beydon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Physiologie\u2010Explorations Fonctionnelles Respiratoires (EFR), AP\u2010HP H\u00f4pital Armand\u2010Trousseau Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"De Blic","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et d\u2019Allergologie P\u00e9diatriques, AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades Paris France"},{"name":"Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Gabet","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153 \u2010 CRESS, HERA (Health Environmental Risk Assessment) research unit Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lezmi","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et d\u2019Allergologie P\u00e9diatriques, AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades Paris France"},{"name":"Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Amat","sequence":"additional","affiliation":[{"name":"Service d\u2019Allergologie P\u00e9diatrique, AP\u2010HP H\u00f4pital d\u2019Enfants Armand\u2010Trousseau Paris France"},{"name":"Universit\u00e9 Paris Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2247","authenticated-orcid":false,"given":"Fanny","family":"Ranci\u00e8re","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153 \u2010 CRESS, HERA (Health Environmental Risk Assessment) research unit Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Momas","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153 \u2010 CRESS, HERA (Health Environmental Risk Assessment) research unit Universit\u00e9 Paris Descartes \u2010 Sorbonne Paris Cit\u00e9 Paris France"},{"name":"Cellule Cohorte Mairie de Paris, Direction de l\u2019Action Sociale de l\u2019Enfance et de la Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70277-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0542-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03541.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12208"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001748"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111922"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-007-9109-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_8_10_1","unstructured":"PinartM MaierD Gimeno\u2010SantosE et al.Systematic Review Protocol to Define Classical IgE\u2010Associated Diseases from Birth to Adolescence: The MeDALL Study. 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