{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:02:15Z","timestamp":1782475335612,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pollen\u2010related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross\u2010sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large cohort of children with SAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During 2015\u20102017 (follow\u2010up), we re\u2010examined 401 patients from those enrolled in 2009\u20102011 (baseline) by the \u201cPanallergens in Pediatrics\u201d study, a large multicenter survey of Italian children with SAR. Information on clinical history (standard questionnaire, AllergyCARD\u00ae; TPS, Italy) and skin prick tests for inhalant and foods extracts (ALK\u2010Abell\u00f3, H\u00f8rsholm, Denmark) was acquired as at baseline visit. Evolution in clinical and sensitization data of patients was analyzed over time, as well as their association with the main baseline characteristics and atopy risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of participants was 10.4\u00a0\u00b1\u00a03.4\u00a0years at baseline and 16.2\u00a0\u00b1\u00a03.6\u00a0years at follow\u2010up. SAR persisted in 93.3% of patients at follow\u2010up and became more frequently associated with asthma (from 36.7% at baseline to 48.6% at follow\u2010up) and oral allergy syndrome (OAS, from 23.4% to 37.7%). Compared to baseline, the prevalence of skin sensitization to some pollens (<jats:italic>Phleum pratense<\/jats:italic>, <jats:italic>Corylus avellana<\/jats:italic>, <jats:italic>Platanus acerifolia<\/jats:italic>, <jats:italic>Artemisia vulgaris<\/jats:italic>) and vegetables (hazelnut, wheat, and apple) significantly decreased at follow\u2010up. Earlier onset of SAR and polysensitization at baseline were associated with incident asthma at follow\u2010up. The presence at baseline of serum IgE to the following allergen molecules was identified as biomarkers of clinical evolution: (a) Phl p 1, for persistence of SAR; (b) Phl p 5, for persistence of both rhinitis and asthma; (c) Pru p 3, for new onset of asthma; (d) Bet v 1, for persistence of OAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Seasonal allergic rhinoconjunctivitis is clinically heterogeneous in its evolution from childhood to adolescence. The detection of serum IgE to specific molecules (Phl p 1, Phl p 5, Bet v 1, Pru p 3) may be useful as biomarkers to predict SAR persistence and future onset of comorbidities, such as asthma and\/or OAS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13036","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T01:35:13Z","timestamp":1549589713000},"page":"325-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-5263","authenticated-orcid":false,"given":"Francesca","family":"Cipriani","sequence":"first","affiliation":[{"name":"Pediatric Unit, Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Panetta","sequence":"additional","affiliation":[{"name":"Consultancy &amp; Training, Biostatistics L\u2019altrastatistica srl Rome Italy"},{"name":"Department of Pediatric Pneumology and Immunology Charite Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charite Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Potapova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charite Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Dondi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charite Medical University Berlin Germany"},{"name":"Pediatric Emergency Unit S. Orsola\u2010Malpighi Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Pediatric Unit San Giuseppe Hospital Empoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caffarelli","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica, Department of Medicine and Surgery University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Casani","sequence":"additional","affiliation":[{"name":"Pediatra di Libera Scelta Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Cervone","sequence":"additional","affiliation":[{"name":"Pediatric Unit San Giuseppe Hospital Empoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Chini","sequence":"additional","affiliation":[{"name":"UOSD di Immunopatologia ed Allergologia Pediatrica, Policlinico Tor Vergata Universit\u00e0 di Roma Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Comberiati","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Paediatrics University of Pisa Pisa Italy"},{"name":"Department of Clinical Immunology and Allergology I.M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"De Castro","sequence":"additional","affiliation":[{"name":"Pediatric Department La Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Miraglia Del Giudice","sequence":"additional","affiliation":[{"name":"Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica Universit\u00e0 della Campania Luigi Vanvitelli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iride","family":"Dello Iacono","sequence":"additional","affiliation":[{"name":"Pediatric Unit Fatebenefratelli Hospital Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Di Rienzo Businco","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit Sandro Pertini Hospital Rome 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