{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:25:00Z","timestamp":1771010700827,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["VIDI 016.136.361"],"award-info":[{"award-number":["VIDI 016.136.361"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102014\u2010CoG\u2010648916"],"award-info":[{"award-number":["ERC\u20102014\u2010CoG\u2010648916"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["733206"],"award-info":[{"award-number":["733206"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["529051014"],"award-info":[{"award-number":["529051014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. Fetal blood flow adaptations might contribute to these associations. We examined the associations of fetal umbilical, cerebral, and pulmonary blood flow with wheezing patterns, lung function, and asthma in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based prospective cohort study among 903 children, we measured fetal umbilical, cerebral, and pulmonary blood flow by pulsed\u2010wave Doppler at a median gestational age of 30.3 (95% range 28.8\u201032.3) weeks. We obtained information about wheezing patterns until the age of 6\u00a0years by questionnaires. Lung function was measured by spirometry and information about current asthma was obtained by questionnaire at the age of 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed a non\u2010significant relationship between a higher umbilical artery pulsatility index (PI) and umbilical artery PI\/cerebral artery PI ratio, indicating fetal blood flow redistribution at the expense of the trunk, with higher risks of early wheezing (OR [95% CI]: 2.07 (0.70\u20106.10) and 2.74 (0.60, 12.62) per unit increase, respectively). A higher pulmonary artery time velocity integral, indicating higher pulmonary vascular resistance, was associated with a higher risk of late\/persistent wheezing (Z\u2010score 1.14 [1.01\u20101.29]). A higher middle cerebral artery PI was associated with a higher FEV<jats:sub>1<\/jats:sub>\/FVC (Z\u2010score [95% CI]: 0.21 [0.01\u20100.42]). Results did not materially change after additional adjustment for birth and growth characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Third\u2010trimester fetal blood flow patterns might be related to childhood respiratory health. These findings should be considered as hypothesis generating and need further replication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13044","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T04:37:26Z","timestamp":1551155846000},"page":"443-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fetal umbilical, cerebral and pulmonary blood flow patterns in relation to lung function and asthma in childhood. The Generation R Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Marjolein N.","family":"Kooijman","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelien R.","family":"van Meel","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Division of Respiratory Medicine and Allergology, Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A. P.","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W. 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