{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:10:39Z","timestamp":1768943439875,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact sensitization in children is increasing. The offending allergens differ depending on patient age and sex. We aimed to determine the sensitization profiles in children (aged 6\u201012) and adolescents (aged 13\u201018), to compare these to a control group of adults (aged 60\u201066), and to evaluate differences in sensitization patterns between working and non\u2010working adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Materials\/Methods<\/jats:title><jats:p>We analyzed Information Network of Departments of Dermatology (IVDK) data from 2009 to 2016 using multiple logistic regression analysis. Of the 99\u00a0082 patients documented in the IVDK database, 591 children, 2451 adolescents and 12\u00a0122 adults were included in further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nickel was the most frequent contact allergen among all age\u2010groups. Children and adolescents showed significantly lower reaction rates to fragrance mix, methyldibromo\u2010glutaronitrile, methylisothiazolinone, and propolis than adults. Positive reactions to sorbitan sesquioleate and mercapto mix among children and to cobalt among adolescents were significantly more frequent than in adults. Working adolescents had more often positive reactions to methyl(chloro)isothiazolinone (skin lesions predominantly on hands) and paraben mix (skin lesions predominantly on feet) when compared to non\u2010working peers. Patch\u2010tested children were more often diagnosed with atopic dermatitis than adults (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contact allergens display age\u2010specific patterns, which should be considered in a standardized series targeting different patient populations (children and adolescents). Employed adolescents should preferably be tested with the baseline series to optimize allergen identification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13069","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T20:44:05Z","timestamp":1557607445000},"page":"632-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A case\u2010control analysis of skin contact allergy in children and adolescents"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-9876","authenticated-orcid":false,"given":"Wojciech","family":"Francuzik","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Schubert","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin 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