{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:00:44Z","timestamp":1790632844307,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ANR within the framework of the \u201cFuture Investments\u201d program","award":["ANR-11- EQPX-0038"],"award-info":[{"award-number":["ANR-11- EQPX-0038"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Partially hydrolyzed formulas (pHF) are recommended in non\u2010breastfed infants with familial history of allergy to prevent allergy development. However, recent meta\u2010analysis does not provide strong support for their protective effect. The present work assesses the links between 2\u2010month infant formula use and the incidence of eczema, respiratory symptoms, or food allergies (FA) up to 2\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The nationwide ELFE birth cohort is a population\u2010based study from mainland France. Infant feeding (breast milk only, partially hydrolyzed formula with [pHF\u2010HA] or without a hypoallergenic label [pHF\u2010non\u2010HA], and non\u2010hydrolyzed formula [Nhf]) was reported at 2\u00a0months. Eczema, FA, and respiratory symptoms such as wheezing and asthma were reported at 2\u00a0months, 1\u00a0year, and 2\u00a0years. Infants with prior FA at 2\u00a0months were excluded from analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 11\u00a0720 infants, those who received only breast milk at 2\u00a0months were at lower risk of eczema at 1\u00a0year than those who received nHF (OR[95% CI]\u00a0=\u00a00.78[0.65\u20100.94] in non\u2010at\u2010risk infants; 0.86[0.75\u20100.98] in at\u2010risk infants). The use of pHF\u2010HA, compared with nHF, at 2\u00a0months was related to higher risk of wheezing at 1\u00a0year in at\u2010risk infants (1.68[1.24\u20102.28]) and higher risk of FA at 2\u00a0years both in non\u2010at\u2010risk infants (3.78[1.52\u20109.41]) and in at\u2010risk infants (2.31[1.36\u20103.94]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this nationwide study, pHF\u2010HA use was not associated with a lower risk of any of the studied outcomes. Quite the reverse, it was associated with a higher risk of wheezing and FA. This should be confirmed in further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13094","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:01:34Z","timestamp":1560787294000},"page":"614-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Use of partially hydrolysed formula in infancy and incidence of eczema, respiratory symptoms or food allergies in toddlers from the ELFE cohort"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-7351","authenticated-orcid":false,"given":"Camille","family":"Davisse\u2010Paturet","sequence":"first","affiliation":[{"name":"INSERM, UMR 1153 Centre for Research in Epidemiology and StatisticS (CRESS) Research Team on EARly Life Origins of Health (EAROH) Paris France"},{"name":"Universit\u00e9 de Paris Paris 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Lorraine Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Bois","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Inserm\u2010Ined\u2010EFS Elfe INED Paris France"},{"name":"Service D\u00e9partemental de PMI Conseil D\u00e9partemental des Hauts\u2010de\u2010Seine Nanterre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010No\u00eblle","family":"Dufourg","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Inserm\u2010Ined\u2010EFS Elfe INED Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-7820","authenticated-orcid":false,"given":"Sandrine","family":"Lioret","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1153 Centre for Research in Epidemiology and StatisticS (CRESS) Research Team on EARly Life Origins of Health (EAROH) Paris France"},{"name":"Universit\u00e9 de Paris Paris 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