{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:27:44Z","timestamp":1790785664101,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal alcohol exposure (PAE) has well\u2010known teratogenic effects on the developing fetus, potentially resulting in neurologic impairments. However, there is increasing interest regarding other potential adverse health outcomes related to prenatal alcohol exposure. The objective of this study was to\u00a0undertake a systematic review to identify all the available clinical and preclinical literature investigating immune\u2010related outcomes in offspring with PAE. A\u00a0systematic review searching four electronic databases (PubMed, CINAHL, Web of Science, and Embase)\u00a0was conducted. Potential articles were screened against strict inclusion\/exclusion criteria. This review specifically focused on evaluating studies related to immune\u2010related outcomes following PAE. Twelve clinical studies were included in the current review. Six included allergy outcomes, four included infection outcomes, and two studies included both. Thirty\u2010nine preclinical studies were identified examining a wide range of immune outcomes. The current review provides some preliminary clinical evidence that PAE can influence immune function, including atopic allergy and infection outcomes. However, there was variability in results across studies, particularly in the atopy area. Preclinical studies demonstrated some changes in lymphocytes and cytokines in offspring following PAE. More research investigating the effects of PAE on immune responses is warranted.<\/jats:p>","DOI":"10.1111\/pai.13099","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T10:05:35Z","timestamp":1560938735000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune\u2010related outcomes"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-5613","authenticated-orcid":false,"given":"Natasha","family":"Reid","sequence":"first","affiliation":[{"name":"Child Health Research Centre The University of Queensland South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-0034","authenticated-orcid":false,"given":"Karen 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