{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:45:41Z","timestamp":1791585941473,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R16\u2010A1694"],"award-info":[{"award-number":["R16\u2010A1694"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["903516"],"award-info":[{"award-number":["903516"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["0603\u201000280B"],"award-info":[{"award-number":["0603\u201000280B"]}],"id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between allergic sensitization during childhood and risk of developing asthma remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze single time\u2010point and temporal patterns of sensitization in childhood in relation to asthma at age 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Specific IgE (sIgE) level and skin prick test (SPT) toward 22 food allergens and aeroallergens were assessed at 6, 18\u00a0months, 4, 6, and 13\u00a0years in children from the high\u2010risk Copenhagen Prospective Studies on Asthma in Childhood<jats:sub>2000<\/jats:sub> (COPSAC<jats:sub>2000<\/jats:sub>) mother\u2010child cohort. We analyzed the association between single time\u2010point monosensitization, polysensitization, and quantitative assessment of sensitization, that is, sum of all sIgE levels and SPT wheal sizes, against asthma at age 13. In addition, we analyzed the association between three temporal patterns of sensitization: (a) early\u2010transient, (b) late\u2010onset, and (c) persistent sensitization and asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Polysensitization status measured by SPT or sIgE was at all single time\u2010points associated with increased risk of asthma at age 13: OR range, SPT\u00a0=\u00a03.0\u201015.7, and sIgE\u00a0=\u00a02.6\u201015.7, respectively, whereas monosensitization status was inconsistently associated with asthma. Quantitative assessment of both sIgE and SPT results was associated with asthma at all single time\u2010points: OR range, SPT\u00a0=\u00a01.3\u20103.6, and sIgE\u00a0=\u00a01.1\u20101.7. Persistent sensitization, but not early\u2010transient or late\u2010onset sensitization was associated with asthma by age 13: OR [95% CI], SPT\u00a0=\u00a08.9 [2.8\u201028.23], and sIgE\u00a0=\u00a02.9 [1.1\u20107.6], respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensitization to multiple allergens at single time\u2010points, increasing sIgE levels and SPT wheal sizes, and persistent sensitization during childhood were associated with increased risk of asthma at age 13, suggesting the use of quantitative and repetitive sensitization measurements when assessing risk of developing asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13109","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T19:39:18Z","timestamp":1562960358000},"page":"716-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Single and multiple time\u2010point allergic 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