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Usually, wheezing episodes are recorded retrospectively, which may induce recall bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and objectives<\/jats:title><jats:p>The aim of this study was to investigate true\u2010positive recall of parent\u2010reported wheeze at 1\u00a0year of age, its determinants, and its implications for asthma and lung function at 6\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PASTURE (Protection Against Allergy\u2014Study in Rural Environments) study followed 880 children from rural areas in 5 European countries from birth to age 6\u00a0years. Wheeze symptoms in the first year were asked weekly. At age 6, parent\u2010reported asthma diagnosis was ascertained and lung function measurements were conducted. Correct parental recall of wheeze episodes at the end of the first year was assessed for associations with lung function, asthma, and the asthma risk locus on chromosome 17q21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parents correctly recalled wheeze after the first year in 54% of wheezers. This true\u2010positive recall was determined by number of episodes, timing of the last wheeze episode, and parental asthma. Independently from these determinants, true\u2010positive recall predicted asthma at age 6\u00a0years (odds ratio 4.54, 95% confidence interval (CI) [1.75\u201014.16]) and impaired lung function (\u03b2\u00a0=\u00a0\u22120.62, 95% CI [\u22121.12; \u22120.13], <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.02). Associations were stronger in children with asthma risk SNPs on chromosome 17q21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Correct parental recall of wheezing episodes may reflect clinical relevance of early wheeze and its impact on subsequent asthma and lung function impairment. Questions tailored to parental perception of wheezing episodes may further enhance asthma prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13118","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:19:10Z","timestamp":1566573550000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-3077","authenticated-orcid":false,"given":"Tabea","family":"Brick","sequence":"first","affiliation":[{"name":"Dr von Hauner Children\u2019s Hospital Ludwig Maximilians University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hose","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children\u2019s Hospital 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Helsinki Helsinki Finland"},{"name":"Department of Health Security National Institute for Health and Welfare Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Divaret\u2010Chauveau","sequence":"additional","affiliation":[{"name":"UMR\/CNRS 6249 Chrono\u2010Environment University of Bourgogne Franche Comt\u00e9 Besan\u04abon France"},{"name":"Pediatric Allergy Department University Hospital of Nancy Nancy France"},{"name":"EA3450 DevAH\u2010Department of Physiology Faculty of Medicine University of Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Dalphin","sequence":"additional","affiliation":[{"name":"UMR\/CNRS 6249 Chrono\u2010Environment University of Bourgogne Franche Comt\u00e9 Besan\u04abon France"},{"name":"Department of Respiratory Disease University Hospital of Besan\u04abon Besan\u04abon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-3923","authenticated-orcid":false,"given":"Markus J.","family":"Ege","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children\u2019s Hospital Ludwig Maximilians University of Munich Munich Germany"},{"name":"Member of the German Center for Lung Research Comprehensive Pneumology Center Munich (CPC\u2010M) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PASTURE study 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