{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:42:12Z","timestamp":1788471732825,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A missense variant (rs6967330) of the gene encoding cadherin\u2010related family member 3 (<jats:italic>CDHR3<\/jats:italic>) was associated with recurrent severe exacerbations in pre\u2010schoolers. However, there were limited data on its relationship with pre\u2010school lung function and school\u2010age asthma. This study replicated the association between polymorphic markers at the region of <jats:italic>CDHR3<\/jats:italic> around rs6967330 and wheezing phenotypes in two independent cohorts of Chinese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten tagging SNPs located 10\u00a0kb around rs6967330 were selected by HaploView 5.0 based on 1000 Genomes database for Southern Han Chinese. Their associations with wheezing and lung function were examined in 1341 Chinese pre\u2010school children, while those for asthma phenotypes were examined in an independent group of 2079 school\u2010age children. Genotypic and haplotypic associations were analyzed by multivariate regression, and generalized multifactor dimensionality reduction was used to examine epistatic interactions for wheezing traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (SD) age of pre\u2010school cohort was 4.7 (1.0) years. Rs6967330 was associated with current wheeze (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.09\u20102.43) and its severity (OR 1.64, 95% CI 1.10\u20102.44) among pre\u2010school children. This SNP was also associated with school\u2010age asthma (OR 1.32, 95% CI 1.04\u20101.69). The minor allele of rs408223 was associated with lower FEV<jats:sub>0.5<\/jats:sub> (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22122.411, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) and FEV<jats:sub>0.5<\/jats:sub>\/FVC (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22121.292, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Lower spirometric indices were also associated with minor allele of rs140154310. GAC haplotype from rs4730125, rs6967330, and rs408223 was associated with pre\u2010school current wheeze and school\u2010age asthma. Epistatic interaction was found between unrelated <jats:italic>CDHR3<\/jats:italic> SNPs for FEV<jats:sub>0.5<\/jats:sub> among pre\u2010schoolers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>CDHR3<\/jats:italic> is a candidate gene for early\u2010life wheezing, school\u2010age asthma, and lung function in Chinese children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13138","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T19:51:24Z","timestamp":1571082684000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cadherin\u2010related family member 3 gene impacts childhood asthma in Chinese children"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-1926","authenticated-orcid":false,"given":"Ting Fan","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Paediatrics 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