{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:16:44Z","timestamp":1777465004600,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"S24","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early\u2010life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early\u2010onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the \u201c\u2010omic\u201d technologies to urine, blood and breath condensate, and non\u2010invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.<\/jats:p>","DOI":"10.1111\/pai.13157","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:46:51Z","timestamp":1580791611000},"page":"16-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early\u2010life origin and prevention of chronic obstructive pulmonary diseases"],"prefix":"10.1111","volume":"31","author":[{"given":"Laura","family":"Moschino","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-1225","authenticated-orcid":false,"given":"Silvia","family":"Carraro","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padova Padova Italy"},{"name":"Citt\u00e0 della Speranza Institute of Pediatric Research Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-3652","authenticated-orcid":false,"given":"Eugenio","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padova Padova Italy"},{"name":"Citt\u00e0 della Speranza Institute of Pediatric Research Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00084114"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra067279"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1603287"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60446-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2599LE"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203079"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110-1922OC"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.12.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00255-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.12.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201312-448LD"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12879"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30181-0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210672"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:01:37Z","timestamp":1693875697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":15,"journal-issue":{"issue":"S24","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/pai.13157"],"URL":"https:\/\/doi.org\/10.1111\/pai.13157","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}