{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:28:27Z","timestamp":1759048107882,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"S24","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgE\u2010mediated food allergy (FA) has been emerging as a public health priority, mainly in children. It represents a heavy burden for the entire society and not only for the patients and their families. There is evidence that in children with persistent FA, at least to cow's milk, hen's egg, and peanut, oral immunotherapy (OIT) may increase the reaction threshold to food allergen(s), while receiving active therapy (the so\u2010called \u201cdesensitization\u201d). Furthermore, OIT protects patients from the occurrence of severe reactions in the event of accidental ingestion of the culprit food during treatment. However, many gaps are still unsolved, including safety issues, identification of predictive biomarkers, and post\u2010desensitization efficacy. This article briefly summarizes the current evidence and the main needs in OIT to stimulate the development of longitudinal, prospective, well\u2010designed studies able to fill the current gaps soon.<\/jats:p>","DOI":"10.1111\/pai.13159","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:46:51Z","timestamp":1580791611000},"page":"51-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oral immunotherapy in pediatrics"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-0568","authenticated-orcid":false,"given":"Stefania","family":"Arasi","sequence":"first","affiliation":[{"name":"Pediatric Allergology Unit Department of Pediatric Medicine Bambino Ges\u00f9 Children's Research Hospital (IRCCS) Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Castagnoli","sequence":"additional","affiliation":[{"name":"Pediatric Clinic Foundation IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni B.","family":"Pajno","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Pediatrics University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13319"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0604-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13124"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812856"},{"key":"e_1_2_8_10_1","unstructured":"PrickettS PVX108\u2010A Peptide\u2010Immunotherapy for Peanut Allergy Shows Exceptional Safety in Peanut\u2010Allergic Adults. EAACI annual meeting 2019\u2010Oral comunication."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13393"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:01:45Z","timestamp":1693875705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":10,"journal-issue":{"issue":"S24","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/pai.13159"],"URL":"https:\/\/doi.org\/10.1111\/pai.13159","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"type":"print","value":"0905-6157"},{"type":"electronic","value":"1399-3038"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}