{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:42:36Z","timestamp":1768873356966,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Introduction and gradual incremental escalation of a low dose of baked milk may accelerate the resolution of severe cow's milk (CM) allergy for some children. The purpose of our study was to evaluate the efficacy and safety of baked milk oral immunotherapy (OIT) in children with CM allergy after a low\u2010dose baked milk oral food challenge (OFC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective analysis of OFC performed between 2013 and 2018 at the Children's Hospital of Toulouse (France), we identified 64 children with CM allergy and high milk and casein\u2010specific IgE levels, who underwent a total of 171 milk OFC. Mean age at 1st OFC was 4.8\u00a0years. Mean CM\u2010specific IgE was 47.9 kUA\/L, and mean casein\u2010specific IgE was 42.3 kUA\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most children were treated with baked milk OIT. Our study shows that 67.2% of the children did not react to 1st low\u2010dose baked milk OFC (168.6\u00a0mg of CM protein). Eighteen percent of children stopped the OIT at home. Finally, desensitization to fresh milk was achieved in 27 children (42.2% of children allergic to CM). Children with lower CM\u2010specific IgE levels have a significantly higher probability of becoming desensitized to unbaked CM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most children with CM allergy and high milk and casein\u2010specific IgE levels tolerate the introduction of baked milk. However, the occurrence of anaphylactic reactions during OIT remains possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13216","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T15:38:41Z","timestamp":1579016321000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Benefits of baked milk oral immunotherapy in French children with cow's milk allergy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-2118","authenticated-orcid":false,"given":"Vianney","family":"Gruzelle","sequence":"first","affiliation":[{"name":"Pediatric Pneumo\u2010allergology Department Children's Hospital University Hospital Centre of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Juchet","sequence":"additional","affiliation":[{"name":"Pediatric Pneumo\u2010allergology Department 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