{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:37:13Z","timestamp":1790523433389,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies on the exposure of children to sugar\u2010sweetened beverages (SSBs) at an early age may contribute to better understand the common causes and the temporal order of the relationships between obesity and asthma in early childhood. The objective of this study was to estimate the association between SSB and child asthma traits in the 2nd year of life, modeling direct and indirect pathways mediated by the highest BMI\u2010z of the child and allergic inflammation. Data from the BRISA cohort, S\u00e3o Lu\u00eds\u2010MA, Brazil (n\u00a0=\u00a01140), were obtained from the baseline and from the follow\u2010up performed at the 2nd year of life. The main explanatory variable was the calories from added sugars in SSBs as a percentage of the total daily energy intake. The outcome child asthma traits was a latent variable deduced from four indicators: medical diagnosis of asthma, wheezing, emergency visit due to intense wheezing, and medical diagnosis of rhinitis. A high percentage of daily calories from sugars added to SSBs was directly associated with higher values of child asthma traits (standardized coefficient (SC\u00a0=\u00a00.073; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.030)). High levels of eosinophils were also directly associated with child asthma traits (SC\u00a0=\u00a00.118; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049). No mediation pathways were observed via greater BMI\u2010z or eosinophil counts. Therefore, early exposure of children to SSB may contribute to increased risk of childhood asthma, preceding the link between sugar consumption and overweight\/obesity, not yet evident in children in the first 2\u00a0years of life.<\/jats:p>","DOI":"10.1111\/pai.13243","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T17:21:39Z","timestamp":1583947299000},"page":"480-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pathways in the association between sugar sweetened beverages and child asthma traits in the 2nd year of life: Findings from the BRISA cohort"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-2726","authenticated-orcid":false,"given":"Luana Lopes","family":"Padilha","sequence":"first","affiliation":[{"name":"Department of Public Health Postgraduate Program in Collective Health Federal University of Maranh\u00e3o (UFMA) S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcio Oliveira","family":"Vianna","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical School of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa Tal\u00edcia Machado","family":"Vale","sequence":"additional","affiliation":[{"name":"Department of Public Health Postgraduate Program in Collective Health Federal University of Maranh\u00e3o (UFMA) S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelma Ximenes Prado Teixeira","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Physiological and Health Sciences UFMA S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Augusto Moura","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Public Health Postgraduate Program in Collective Health Federal University of Maranh\u00e3o (UFMA) S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Claudia Costa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Public Health Postgraduate Program in Collective Health Federal University of Maranh\u00e3o (UFMA) S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention 2016. 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