{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:10:59Z","timestamp":1768317059073,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eczema is a growing threat on infants\u2019 health, and the role of maternal depression in the risk of eczema's early onset is unclear. This study aimed to examine the associations of different exposure timing of prenatal depressive symptoms with offspring's eczema in infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was part of the ongoing prospective Born in Guangzhou Cohort Study. Maternal depressive symptoms were assessed at both early (&lt;20th week of gestation) and late pregnancy (\u226533rd week of gestation to delivery) using the Self\u2010Rating Depression Scale. Information on the diagnosis of eczema was collected\u00a0when the children were 1 year old. Multivariable logistic regression was used to examine the association between prenatal depressive symptoms and infants\u2019 eczema and test for moderation by parental history of allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this population, 7.7% (447\/5825) of mothers experienced persistent depressive symptoms during pregnancy, 10.1% (590\/5825) had depressive symptoms only at early pregnancy, and 8.4% (489\/5825) of women experienced depressive symptoms only at late pregnancy. After adjusting for potential confounders, higher risks of eczema were observed in infants of mothers with persistent prenatal depressive symptoms when compared to those children without maternal depressive symptoms throughout pregnancy (OR: 1.55, 95% CI 1.19\u20102.03). These associations were marginally more pronounced among children in families without parents affected by allergic diseases than in other families (<jats:italic>P<\/jats:italic> for interaction\u00a0=\u00a0.064 for courses of prenatal depressive symptoms).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Persistent maternal depressive symptoms during pregnancy increased the risk of infants\u2019 eczema, especially in children without family history of allergic diseases. These associations, if proved to be causal, could be an intervention target not only to improve women's health but also to prevent offspring's eczema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13254","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T04:58:37Z","timestamp":1587099517000},"page":"662-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between prenatal depressive symptoms and eczema in infants: The Born in Guangzhou Cohort Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Dongmei","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University Guangzhou 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