{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:24:24Z","timestamp":1778599464324,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Worldwide, the number of SARS\u2010CoV\u20102 infections is increasing. Serological immunoglobulin tests may help to better understand the development of immune mechanisms against SARS\u2010CoV\u20102 in COVID\u201019 cases and exposed but asymptomatic individuals. The aim of this study was to investigate exposure to SARS\u2010CoV\u20102, symptoms, and antibody responses in a large sample of healthcare workers following a COVID\u201019 outbreak.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A COVID\u201019 outbreak among staff members of a major German children's and women's hospital was followed by massive RT\u2010PCR SARS\u2010CoV\u20102 tests and provided the opportunity to study symptoms, chains of infection, and SARS\u2010CoV\u20102\u2013specific antibody responses (IgG and IgA) by ELISA. Study participants were classified as COVID\u201019 cases, and persons with close, moderate, or no exposure to SARS\u2010CoV\u20102 in the clinical setting, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 201 study participants, 31 were COVID\u201019 cases. While most study participants experienced many symptoms indicative for SARS\u2010CoV\u20102 infection, anosmia and coughing were remarkably more frequent in COVID\u201019 cases. Approximately 80% of COVID\u201019 cases developed some specific antibody response (IgA and IgG) approximately 3\u00a0weeks after onset of symptoms. Subjects in the non\u2010COVID\u201019 groups had also elevated IgG (1.8%) and IgA values (7.6%) irrespective of contact history with cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that a significant number of diseased did not develop relevant antibody responses three weeks after symptom onset. Our data also suggest that exposure to COVID\u201019 positive co\u2010workers in a hospital setting is not leading to the development of measurable immune responses in a significant proportion of asymptomatic contact persons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13278","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T03:53:06Z","timestamp":1589601186000},"page":"841-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Symptoms and immunoglobulin development in hospital staff exposed to a SARS\u2010CoV\u20102 outbreak"],"prefix":"10.1111","volume":"31","author":[{"given":"Susanne","family":"Brandstetter","sequence":"first","affiliation":[{"name":"Research and Development Campus Regensburg (WECARE) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"},{"name":"University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samra","family":"Roth","sequence":"additional","affiliation":[{"name":"Research and Development Campus Regensburg (WECARE) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Harner","sequence":"additional","affiliation":[{"name":"Research and Development Campus Regensburg (WECARE) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Buntrock\u2010D\u00f6pke","sequence":"additional","affiliation":[{"name":"Research and Development Campus Regensburg (WECARE) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"},{"name":"University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoaneta A.","family":"Toncheva","sequence":"additional","affiliation":[{"name":"University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha","family":"Borchers","sequence":"additional","affiliation":[{"name":"University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Gruber","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Microbiology and Hygiene Hospital of the Order of St. John Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ambrosch","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Microbiology and Hygiene Hospital of the Order of St. John Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-1871","authenticated-orcid":false,"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[{"name":"Research and Development Campus Regensburg (WECARE) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"},{"name":"University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization (WHO).Corona virus disease (COVID\u201019) Pandemic.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019. Accessed April 29 2020."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200841"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.065"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa344"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13265"},{"key":"e_1_2_10_7_1","unstructured":"Robert\u2010Koch\u2010Institute Berlin Germany.Strategies for managing contact persons in health care workers.https:\/\/www.rki.de\/DE\/Content\/InfAZ\/N\/Neuartiges_Coronavirus\/HCW.html. Accessed April 16 2020."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2196-x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:01:23Z","timestamp":1693854083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13278"}},"subtitle":[],"editor":[{"given":"\u00d6mer","family":"Kalayc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/pai.13278"],"URL":"https:\/\/doi.org\/10.1111\/pai.13278","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13278\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13278\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13278\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13278\/v1\/review1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]},"assertion":[{"value":"2020-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}