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This reaction often leads to difficulty in breathing and can result in death. The estimated prevalence of anaphylaxis is 0.05%\u20132%, which is reported to be increasing in children. Although drugs and venom are the most common causes of anaphylaxis in adults, food is the most common cause of anaphylaxis in children. An interesting association between food\u2010dependent exercise\u2010induced anaphylaxis (FDEIA) and oral immunotherapy (OIT) has recently been reported. A provocation test to determine the diagnostic and augmenting factors of FDEIA has been reported in recent years. Remarkably, several articles showed allergic symptoms without exercise in children with FDEIA and in those with FDEIA development after OIT. Regarding OIT, full\u2010dose OIT poses a risk of adverse reactions, including anaphylaxis. Recent trials have shown the efficacy and safety of low\u2010dose OIT in patients with food\u2010induced anaphylaxis. In this review, we summarized the novel insights regarding anaphylaxis in the pediatric population.<\/jats:p>","DOI":"10.1111\/pai.13307","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T03:59:11Z","timestamp":1591761551000},"page":"879-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Novel insights regarding anaphylaxis in children \u2010 With a focus on prevalence, diagnosis, and treatment"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-9044","authenticated-orcid":false,"given":"Ken\u2010Ichi","family":"Nagakura","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Sagamihara National Hospital Kanagawa Japan"},{"name":"Department of Pediatrics Jikei University School of Medicine Tokyo 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