{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:20Z","timestamp":1790151260292,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The literature includes scarce data on infants with food\u2010induced anaphylaxis (FIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Medical records of the patients diagnosed with FIA aged 0\u20106\u00a0years between 2015 and 2020 were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, there were 451 instances of FIA in 314 patients, of which 175 (38.8%) occurred in 160 infants (50.9%). The median (IQR) age of infants was 7 months (6\u20109 months) with a male predominance (67.5%), of which 7.5% had multiple instances (\u22652) and 60% atopic dermatitis. The most common triggers were cow\u2019s milk (51.4%), tree nuts (16.6%), and hen\u2019s egg (15.4%), whereas tree nut was the most common trigger in toddlers (35.8%) and preschool children (35.2%). Skin and neurologic symptoms, and nausea\u2010vomiting occurred more frequently (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\u2264\u00a0.001, and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003, respectively), whereas respiratory symptoms occurred less commonly in infants compared to toddlers and preschool children (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\u2264\u00a0.001). In infants, 65 (37.1%) mild, 92 (52.6 %) moderate, and 18 (10.3%) severe episodes of anaphylaxis were detected. History of recurrent wheezing (OR: 6.837 [95% CI: 1.940\u201024.097],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003) and tree nut allergy (OR: 2.849 [95% CI: 1.056\u20107.688],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.039) were found to be independent risk factors for moderate\u2010to\u2010severe anaphylactic reactions. 40.6% of the infants received\n                      <jats:italic>\u00a0<\/jats:italic>\n                      adrenaline, which was lower than the toddlers (49.7%) and preschool children (57.6%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      There is no doubt that\n                      <jats:bold>\u00a0<\/jats:bold>\n                      food\u2010induced anaphylaxis is a medical emergency, specifically in young children. Pediatricians should be aware of the distinct features of infant anaphylaxis, particularly gastrointestinal and neurologic symptoms to provide effective treatment as soon as possible.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13320","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T06:26:02Z","timestamp":1594621562000},"page":"954-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Food\u2010induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-4690","authenticated-orcid":false,"given":"Melike","family":"Kahveci","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-3408","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7972-3436","authenticated-orcid":false,"given":"Gizem","family":"Koken","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-913X","authenticated-orcid":false,"given":"Umit M.","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-251X","authenticated-orcid":false,"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-6850","authenticated-orcid":false,"given":"Bulent E.","family":"Sekerel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03954.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01315.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61086-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.10.052"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.05.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2015-0153"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12437"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01421.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505996"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180507115115"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13519"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.12.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.038"},{"key":"e_1_2_9_18_1","unstructured":"https:\/\/apps.fas.usda.gov\/newgainapi\/api\/Report\/DownloadReportByFileName?fileName=Tree%20Nuts%20Annual_Ankara_Turkey_09\u201015\u20102019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.07.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4211"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328355b7e4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.025"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.10.017"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.05.025"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2017.38.4009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.07.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03276.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3658"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T09:40:31Z","timestamp":1693647631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13320"}},"subtitle":[],"editor":[{"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/pai.13320"],"URL":"https:\/\/doi.org\/10.1111\/pai.13320","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13320\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13320\/v2\/response1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}