{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:16Z","timestamp":1772160856745,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, there are no reliable clinical tools available for predicting asthma in pre\u2013school\u2010aged children with recurrent wheezing. The aim of this study was to evaluate the usefulness of serum periostin, YKL\u201040, and osteopontin biomarkers in wheezy pre\u2013school\u2010aged children for predicting the development of asthma in school ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was prospectively conducted between 2011 and 2017. The clinical features of the pre\u2013school\u2010aged children with recurrent wheezing and the levels of serum periostin, YKL\u201040, and osteopontin were measured. The same participants were reevaluated in school\u2010age period, and participants with asthma were identified. Relative risk (RR) for the development of asthma was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 197 pre\u2013school\u2010aged children with recurrent wheezing who were reevaluated in school\u2010age years, 32% of them had asthma. Serum periostin, YKL\u201040, and osteopontin levels at admission could not predict participants who would have asthma symptoms in school\u2010age years. The RR for continuing of asthma symptoms was higher in participants who had their first wheezing episode before 1\u00a0year of age, preterm birth, cesarean section delivery, prenatal smoking exposure, multi\u2010trigger wheezing, parental asthma, modified asthma predictive index positivity, prophylactic vitamin D intake\u00a0\u2264\u00a012\u00a0months, breastfeeding time\u00a0\u2264\u00a012\u00a0month, and aeroallergen sensitivity [RR (95% CI) and P value: 2.813 (1.299\u20106.091), 0.002; 1.972 (1.274\u20103.052), 0.009; 1.929 (1.195\u20103.114), 0.004; 2.232 (1.463\u20103.406), &lt;0.001; 3.152 (1.949\u20105.097), &lt;0.001; 1.730 (1.144\u20102.615), 0.016; 2.427 (1.559\u20103.777), &lt;0.001; 2.955 (1.558\u20105.604), &lt;0.001; 1.767 (1.084\u20102.881), 0.016; 0.765 (0.556\u20101.053), 0.016; respectively].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results have shown that clinical features were more valuable than biomarkers in predicting having asthma in school\u2010age years in participants who had recurrent wheezing in pre\u2013school\u2010age period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13329","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:56:05Z","timestamp":1597262165000},"page":"77-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Can serum periostin, YKL\u201040, and osteopontin levels in pre\u2010school children with recurrent wheezing predict later development of asthma?"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-5221","authenticated-orcid":false,"given":"Hakan","family":"Guvenir","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-969X","authenticated-orcid":false,"given":"Betul","family":"Buyuktiryaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"},{"name":"Department of Pediatric Allergy Faculty of Medicine Koc University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur","family":"Kulhas Celik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersoy","family":"Civelek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Kilic Suloglu","sequence":"additional","affiliation":[{"name":"Department of Biology, Zoology Section Faculty of Science Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagatay","family":"Karaaslan","sequence":"additional","affiliation":[{"name":"Department of Biology Molecular Biology Section Faculty of Science Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcan","family":"Genc","sequence":"additional","affiliation":[{"name":"Department of Biology Molecular Biology Section Faculty of Science Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Dibek Misirlioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-0551","authenticated-orcid":false,"given":"Muge","family":"Toyran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayfur","family":"Ginis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-7187","authenticated-orcid":false,"given":"Can N.","family":"Kocabas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology Faculty of Medicine Mugla Sitki Kocman University Mugla Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60615-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2004.03.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00005903"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00320"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000599"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12828"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2018.0886"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.1.16"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"e_1_2_10_15_1","unstructured":"Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention (updated 2019).2019.https:\/\/ginasthma.org\/wp\u2010content\/uploads\/2019\/06\/GINA\u20102019\u2010main\u2010report\u2010June\u20102019\u2010wms.pdf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1537OC"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.09.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13181"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12599"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12575"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2017-000680"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0144"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12457"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.05.024"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.01.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2017.01.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519860684"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S128319"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0753-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-7622-11-5"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:10:06Z","timestamp":1693588206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13329"}},"subtitle":[],"editor":[{"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/pai.13329"],"URL":"https:\/\/doi.org\/10.1111\/pai.13329","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.13329\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13329\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13329\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13329\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13329\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.13329\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}