{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:54:51Z","timestamp":1780916091079,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paracetamol, a non\u2010steroidal anti\u2010inflammatory drug, is commonly being used for fever and pain relief worldwide. The aim of this study was to evaluate children with a suspected history of paracetamol hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients who were referred to our clinic in between January 2015 and December 2018 with a suspected history of paracetamol hypersensitivity were included. Reactions were classified according to the European Network for Drug Allergy (ENDA)\/Global Allergy and Asthma European Network classification and European Academy of Allergy and Clinical Immunology (EAACI)\/ENDA Position Paper. Diagnoses were confirmed by skin tests and oral challenge tests (OCTs). In those with verified paracetamol hypersensitivity, an OCT with a strong COX\u20101 inhibitor was performed to classify the type of the reaction to refer as either selective or cross\u2010intolerance hypersensitivity. A subsequent OCT with a selective COX\u20102 inhibitor was performed in those cross\u2010intolerant patients to find out a safe alternative drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty OCTs with paracetamol were performed to patients with a median age of 8.5\u00a0years, and hypersensitivity to paracetamol was verified in 8 patients. Four children were classified as selective responders, and 3 were classified as cross\u2010intolerant after OCT with a COX\u20101 inhibitor. Overall, skin test positivity for paracetamol was detected in only one patient, in whom OCT with paracetamol was negative. In all 3 cross\u2010intolerant patients, a safe alternative non\u2010steroidal anti\u2010inflammatory drug was identified after an OCT with a selective COX\u20102 inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OCT stands as the gold\u2010standard procedure in verifying the diagnosis of patients with paracetamol\u2010induced drug hypersensitivity, as well as, in defining the type of reactions and finding out safe alternative drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13330","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:18:08Z","timestamp":1597277888000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Behind the scene: Paracetamol hypersensitivity in 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