{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:21Z","timestamp":1772160861718,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI129745"],"award-info":[{"award-number":["AI129745"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C) during the COVID\u201019 pandemic raised a global alert from the Centers for Disease Control and Prevention's Health Alert Network. The main manifestations of MIS\u2010C (also known as pediatric MIS (PMIS)) in the setting of a severe inflammatory state include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes. In some cases, these symptoms progressed to multi\u2010organ failure. The low percentage of children with asymptomatic cases compared with mild illness and moderate illness could be correlated with the rare cases of MIS\u2010C. One potential explanation for the progression to severe MIS\u2010C disease despite the presence of readily detectable anti\u2010SARS\u2010CoV\u20102 antibodies could be due to the potential role of antibody\u2010dependent enhancement (ADE). We reason that the incidence of the ADE phenomenon whereby the pathogen\u2010specific antibodies can promote pathology should be considered in vaccine development against SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1111\/pai.13361","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T03:51:03Z","timestamp":1600055463000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The potential threat of multisystem inflammatory syndrome in children during the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-6388","authenticated-orcid":false,"given":"Hussin A.","family":"Rothan","sequence":"first","affiliation":[{"name":"Department of Biology College of Arts and Sciences Georgia State University GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-4640","authenticated-orcid":false,"given":"Siddappa N.","family":"Byrareddy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Centre Omaha NE USA"},{"name":"Department of Genetics, Cell Biology, and Anatomy University of Nebraska Medical Centre Omaha NE USA"},{"name":"Department of Biochemistry and Molecular Biology University of Nebraska Medical Centre Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Multisystem Inflammatory Syndrome in Children (MIS\u2010C) Associated with Coronavirus Disease 2019 (COVID\u201019).https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2023158"},{"issue":"32","key":"e_1_2_11_6_1","first-page":"1074","article-title":"Multisystem Inflammatory Syndrome in Children during the COVID\u201019 pandemic: a case series","volume":"69","author":"Chiotos K","year":"2020","journal-title":"J Pediatr Infect Dis Soc"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2020.101232"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"e_1_2_11_9_1","unstructured":"American College of Rheumatology Clinical guidance for pediatric patients with multisystem inflammatory syndrome in children (MIS\u2010C) associated with SARS\u2010CoV\u20102 and hyperinflammation in COVID\u201019. 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