{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:00Z","timestamp":1787016000374,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/7\/1067\/2013\u2010RCH"],"award-info":[{"award-number":["5\/7\/1067\/2013\u2010RCH"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D supplementations for asthma control had shown inconsistent results. We aimed to study efficacy and safety of vitamin D supplementation in asthmatic children who were vitamin D deficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This double\u2010blind, randomized controlled trial enrolled asthmatic children of 4\u201012\u00a0years of age who had 25\u2010hydroxyvitamin D [25(OH)D] levels &lt;20\u00a0ng\/mL. The participants were randomized to receive either vitamin D orally 1000\u00a0IU\/d for 9\u00a0months or similar\u2010looking placebo. The primary outcomes were the proportion of children having the Childhood Asthma Control Test (CACT) score of \u226520 at the end of the treatment and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The trial included 250 children (125 in each group) with a mean age of 8.1\u00a0\u00b1\u00a02.3\u00a0years and 180 boys. The baseline parameters were similar between the groups, including CACT score (21.7\u00a0\u00b1\u00a04.2 vs 21.9\u00a0\u00b1\u00a03.6, vitamin D vs placebo). At the end of the study, the proportion of asthmatic children who had CACT score\u00a0\u2265\u00a020 was similar between vitamin D and placebo group (93.6% vs 92.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.625). The number of exacerbations of asthma and side effect profile was also identical between the groups. 25(OH)D levels increased significantly in the vitamin D group (18.06\u00a0\u00b1\u00a07.11 vs 12.03\u00a0\u00b1\u00a05.98\u00a0ng\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The results did not change when we did subgroup analysis for children with baseline CACT score\u00a0&lt;\u00a020 and 25(OH)D levels at the end of the study \u226520\u00a0ng\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D supplementation in asthmatic children with vitamin D deficiency did not improve control of asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13415","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T18:42:05Z","timestamp":1605724925000},"page":"479-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: A randomized controlled trial (ESDAC trial)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-246X","authenticated-orcid":false,"given":"Kana Ram","family":"Jat","sequence":"first","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Prakash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Lodha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil K.","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0716"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00456.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.028"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0442"},{"key":"e_1_2_10_6_1","first-page":"11","article-title":"The impact of vitamin D deficiency on immune T cells in asthmatic children: a case\u2010control study","volume":"5","author":"Maalmi H","year":"2012","journal-title":"J Asthma Allergy"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-447OC"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.030"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.209227"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-013-1268-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30306-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_10_15_1","unstructured":"GINA\u20102016\u2010main\u2010report_tracked.pdf[Internet]. 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