{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:26:11Z","timestamp":1785464771620,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of hydrolyzed infant formulas in the prevention of asthma and allergies remains inconsistent. We tested whether extensively hydrolyzed casein formula compared to conventional cow's milk\u2013based formula prevented asthma, allergic rhinitis, or atopic eczema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the randomized double\u2010blind Trial to Reduce IDDM in Genetically at Risk (TRIGR), comparing extensively hydrolyzed to standard cow's milk\u2013based infant formula during the first 6\u20108\u00a0months of life, we assessed the effect of the intervention on the incidence of asthma, allergic rhinitis, and eczema when the children were 9\u2010 to 11\u2010years old. The asthma, allergic rhinitis, and eczema occurrence was assessed using online standardized and validated ISAAC questionnaire. Of the 1106 children who participated in this Ancillary study, 560 had been randomized to the experimental (extensively hydrolyzed casein formula) and 546 to the control arm (cow's milk\u2013based formula).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The risk of persistent asthma, allergic rhinitis, or atopic eczema did not differ by treatment, the hazard ratios (95% CI) being 1.00 (0.66\u20101.52), 0.95 (0.66\u20101.38), and 0.89 (0.70\u20101.15), respectively, in the intention\u2010to\u2010treat analysis. Neither were there any differences in the per\u2010protocol analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Extensively hydrolyzed casein formula did not protect from asthma, rhinitis, or eczema in this population carrying genetic risk for type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.13452","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:48:08Z","timestamp":1610693288000},"page":"670-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of extensively hydrolyzed casein vs. conventional formula on the risk of asthma and allergies: The TRIGR randomized clinical trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-0878","authenticated-orcid":false,"given":"Suvi M.","family":"Virtanen","sequence":"first","affiliation":[{"name":"Health and Well\u2010Being Promotion Unit Finnish Institute for Health and Welfare Helsinki Finland"},{"name":"Faculty of Social Sciences\/Health Sciences Tampere University Tampere Finland"},{"name":"Center for Child Health Research Tampere University and Tampere University Hospital Tampere Finland"},{"name":"Science Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-9834","authenticated-orcid":false,"given":"David","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"Health Informatics Institute Morsani College of Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Couluris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Morsani College of Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkki","family":"Savilahti","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children\u2019s Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Research Program for Clinical and Molecular Metabolism Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and Tampere University Hospital Tampere Finland"},{"name":"Pediatric Research Center Children\u2019s Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Research Program for Clinical and Molecular Metabolism Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Krischer","sequence":"additional","affiliation":[{"name":"Health Informatics Institute Morsani College of Medicine University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TRIGR Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1958"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.09.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514210"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0281"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12118"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1069"},{"key":"e_1_2_10_10_1","first-page":"CD003664","article-title":"Infant formulas containing hydrolysed protein for prevention of allergic disease","volume":"10","author":"Osborn DA","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i974"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19826"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1074"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2006.00063.x"},{"key":"e_1_2_10_15_1","unstructured":"ISAAC.http:\/\/isaac.auckland.ac.nz\/phases\/phasethree\/results\/results.php. 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